HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHIC (HPLC) ANALYSIS OF OLIGOMERIC COMPONENTS OF THE SPERMICIDE NONOXYNOL-9

被引：21

作者：

WALTER, BA ^{[1
]}

DIGENIS, GA ^{[1
]}

机构：

[1] UNIV KENTUCKY,COLL PHARM,LEXINGTON,KY 40536

来源：

PHARMACEUTICAL RESEARCH | 1991年 / 8卷 / 03期

关键词：

HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY; NONOXYNOL-9; IDENTIFICATION;

D O I：

10.1023/A:1015870304964

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The commercially available Nonoxynol-9 spermicide is a multicomponent mixture of oligomers. When Nonoxynol-9 was separated by normal phase gradient HPLC, 17 components were shown to exist in the commercial mixture. These oligomeric components follow a Poisson distribution around the most abundant oligomer, EO 8 (11.7%). Select oligomers were isolated by preparative HPLC (R(t) = 19.6, 34.0, 45.6, 51.2, 61.6, and 79.2 min) and purified by HPLC. These were identified by FAB-MS and NMR to be the oligomers EO 3, EO 6, EO 8, EO 9, EO 11, and EO 16, respectively.

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页码：409 / 411

页数：3

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