A COMPARISON OF INTRAOCULAR-PRESSURE ELEVATING ACTIVITY OF LOTEPREDNOL ETABONATE AND DEXAMETHASONE IN RABBITS

被引：35

作者：

BODOR, N

WU, WM

机构：

[1] Center for Drug Discovery, J. Hillis Miller Health Center, College of Pharmacy, University of Florida, Gainesville, FL 32610

来源：

CURRENT EYE RESEARCH | 1992年 / 11卷 / 06期

关键词：

D O I：

10.3109/02713689209001808

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

A "Soft" corticosteroid, loteprednol etabonate I, designed based on the "inactive metabolite" concept can be used as a safe ophthalmic anti-inflammatory drug. By design, the metabolism of I follows a predicted biotransformation pathway, thus unwanted systemic side effects are avoided. Local side effects are also reduced. Accordingly, in a cross-over study I did not elevate the intraocular pressure (IOP) in rabbits, as opposed to dexamethasone.

引用

页码：525 / 530

页数：6

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