MECHANISTIC STUDIES OF AN ANTIBODY WITH CHORISMATE MUTASE ACTIVITY

被引：8

作者：

SHIN, JA

HILVERT, D

机构：

[1] Scripps Res Inst, DEPT CHEM, LA JOLLA, CA 92037 USA

[2] SCRIPPS RES INST, DEPT BIOL MOLEC, LA JOLLA, CA 92037 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1994年 / 4卷 / 24期

关键词：

D O I：

10.1016/S0960-894X(01)80845-3

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Antibody 1F7 catalyzes the rearrangement of chorismate to prephenate. Its kinetic parameters are unaffected by changes in pH and display no solvent isotope effect or effects from addition of various cationic salts. These results are consistent with high-resolution structural information of 1F7 bound to a transition state analog.

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页码：2945 / 2948

页数：4

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