INSULIN-DEPENDENT DIABETES-MELLITUS

被引：13

作者：

BACH, JF

机构：

[1] Hôpital Neckar, Paris

来源：

CURRENT OPINION IN IMMUNOLOGY | 1991年 / 3卷 / 06期

关键词：

D O I：

10.1016/S0952-7915(05)80011-1

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Type I diabetes occurs as a result of T-cell-mediated beta-cell destruction. Several candidate antigens have been described recently, including glutamic acid decarboxylase, heat shock protein 65 and perpherin. Restricted T-cell receptor V-beta gene usage in non-obese diabetic mice has been suggested but not yet proven. In addition to major histocompatibility genes, several non-H-2 predisposing genes have been mapped on chromosomes 1, 3 and 11.

引用

页码：902 / 905

页数：4

共 33 条

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