INSULIN-DEPENDENT DIABETES-MELLITUS

被引：13

作者：

BACH, JF

机构：

[1] Hôpital Neckar, Paris

来源：

CURRENT OPINION IN IMMUNOLOGY | 1991年 / 3卷 / 06期

关键词：

D O I：

10.1016/S0952-7915(05)80011-1

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Type I diabetes occurs as a result of T-cell-mediated beta-cell destruction. Several candidate antigens have been described recently, including glutamic acid decarboxylase, heat shock protein 65 and perpherin. Restricted T-cell receptor V-beta gene usage in non-obese diabetic mice has been suggested but not yet proven. In addition to major histocompatibility genes, several non-H-2 predisposing genes have been mapped on chromosomes 1, 3 and 11.

引用

页码：902 / 905

页数：4

共 33 条

[11] ESSENTIAL ROLE FOR INTERFERON-GAMMA AND INTERLEUKIN-6 IN AUTOIMMUNE INSULIN-DEPENDENT DIABETES IN NOD/WEHI MICE
CAMPBELL, IL
KAY, TWH
OXBROW, L
HARRISON, LC
[J]. JOURNAL OF CLINICAL INVESTIGATION, 1991, 87 (02) : 739 - 742
[12] ISLET-SPECIFIC T-CELL CLONES FROM NONOBESE DIABETIC MICE EXPRESS HETEROGENEOUS T-CELL RECEPTORS
CANDEIAS, S
KATZ, J
BENOIST, C
MATHIS, D
HASKINS, K
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (14) : 6167 - 6170
[13] AUTOIMMUNITY TO CHAPERONINS IN THE PATHOGENESIS OF ARTHRITIS AND DIABETES
COHEN, IR
[J]. ANNUAL REVIEW OF IMMUNOLOGY, 1991, 9 : 567 - 589
[14] ACCELERATION OF THE ONSET OF DIABETES IN NOD MICE BY THYMECTOMY AT WEANING
DARDENNE, M
LEPAULT, F
BENDELAC, A
BACH, JF
[J]. EUROPEAN JOURNAL OF IMMUNOLOGY, 1989, 19 (05) : 889 - 895
[15] INDUCTION AND THERAPY OF AUTOIMMUNE DIABETES IN THE NON-OBESE DIABETIC (NOD/LT) MOUSE BY A 65-KDA HEAT-SHOCK PROTEIN
ELIAS, D
MARKOVITS, D
RESHEF, T
VANDERZEE, R
COHEN, IR
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (04) : 1576 - 1580
[16] IDENTIFICATION AND MAPPING TO CHROMOSOME-1 OF A SUSCEPTIBILITY LOCUS FOR PERIINSULITIS IN NONOBESE DIABETIC MICE
GARCHON, HJ
BEDOSSA, P
ELOY, L
BACH, JF
[J]. NATURE, 1991, 353 (6341) : 260 - 262
[17] DEPLETION OF RT6.1+ LYMPHOCYTES-T INDUCES DIABETES IN RESISTANT BIOBREEDING WORCESTER (BB/W) RATS
GREINER, DL
MORDES, JP
HANDLER, ES
ANGELILLO, M
NAKAMURA, N
ROSSINI, AA
[J]. JOURNAL OF EXPERIMENTAL MEDICINE, 1987, 166 (02) : 461 - 475
[18] ACCELERATION OF DIABETES IN YOUNG NOD MICE WITH A CD4+ ISLET-SPECIFIC T-CELL CLONE
HASKINS, K
MCDUFFIE, M
[J]. SCIENCE, 1990, 249 (4975) : 1433 - 1436
[19] PREVENTION OF INSULIN-DEPENDENT DIABETES-MELLITUS IN NONOBESE DIABETIC MICE BY TRANSGENES ENCODING MODIFIED I-A BETA-CHAIN OR NORMAL I-E ALPHA-CHAIN
LUND, T
OREILLY, L
HUTCHINGS, P
KANAGAWA, O
SIMPSON, E
GRAVELY, R
CHANDLER, P
DYSON, J
PICARD, JK
EDWARDS, A
KIOUSSIS, D
COOKE, A
[J]. NATURE, 1990, 345 (6277) : 727 - 729
[20] MILLER BJ, 1988, J IMMUNOL, V140, P52

← 1 2 3 4 →