NUCLEOTIDE, DINUCLEOTIDE AND TRINUCLEOTIDE FREQUENCIES EXPLAIN PATTERNS OBSERVED IN CHAOS GAME REPRESENTATIONS OF DNA-SEQUENCES

被引：72

作者：

GOLDMAN, N

机构：

[1] Laboratory of Mathematical Biology, National Institute for Medical Research, London NW7 1AA, The Ridgeway, Mill Hill

来源：

NUCLEIC ACIDS RESEARCH | 1993年 / 21卷 / 10期

关键词：

D O I：

10.1093/nar/21.10.2487

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The chaos game representation (CGR) is a scatter plot derived from a DNA sequence, with each point of the plot corresponding to one base of the sequence. If the DNA sequence were a random collection of bases, the CGR would be a uniformly filled square; conversely, any patterns visible in the CGR represent some pattern (information) in the DNA sequence. In this paper, patterns previously observed in a variety of DNA sequences are explained solely in terms of nucleotide, dinucleotide and trinucleotide frequencies.

引用

页码：2487 / 2491

页数：5