IL-5 AND ITS RECEPTOR - WHICH ROLE DO THEY PLAY IN THE IMMUNE-RESPONSE

被引：54

作者：

KOIKE, M

TAKATSU, K

机构：

[1] Department of Immunology, Institute of Medical Sciences, University of Tokyo, Minato-Ku, Tokyo 108

来源：

INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY | 1994年 / 104卷 / 01期

关键词：

IL-5; RECEPTOR; B CELL; EOSINOPHIL;

D O I：

10.1159/000236702

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

IL-5 is a homodimeric glycoprotein that promotes proliferation and differentiation of activated B cells, and controls the production and functions of some other hematopoietic cells, such as Ly-1(CD5)(+) B cells, eosinophils and basophils. In humans, IL-5 acts as a differentiation and growth factor for eosinophils, and is the major cytokine involved in the production of eosinophilia. IL-5 acts on its target cells through the specific receptor that is composed of two polypeptide chains, a and b. The alpha-chain is unique to IL-5, while the beta-chain is common to IL-5 receptor, IL-3 receptor and granulocyte-macrophage colony stimulating factor (GM-CSF) receptor.

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页码：1 / 9

页数：9

相关论文

共 75 条

[1] CLONING OF CDNA FOR HUMAN T-CELL REPLACING FACTOR (INTERLEUKIN-5) AND COMPARISON WITH THE MURINE HOMOLOG [J].

AZUMA, C ;

TANABE, T ;

KONISHI, M ;

KINASHI, T ;

NOMA, T ;

MATSUDA, F ;

YAOITA, Y ;

TAKATSU, K ;

HAMMARSTROM, L ;

SMITH, CIE ;

SEVERINSON, E ;

HONJO, T .

NUCLEIC ACIDS RESEARCH, 1986, 14 (22) :9149-9158

[2] A NOVEL FAMILY OF GROWTH-FACTOR RECEPTORS - A COMMON BINDING DOMAIN IN THE GROWTH-HORMONE, PROLACTIN, ERYTHROPOIETIN AND IL-6 RECEPTORS, AND THE P75 IL-2 RECEPTOR BETA-CHAIN [J].

BAZAN, JF .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1989, 164 (02) :788-795

[3] HUMAN INTERLEUKIN-5 INDUCES STAPHYLOCOCCAL-A COWAN-1 STRAIN-ACTIVATED HUMAN B-CELLS TO SECRETE IGM [J].

BERTOLINI, JN ;

SANDERSON, CJ ;

BENSON, EM .

EUROPEAN JOURNAL OF IMMUNOLOGY, 1993, 23 (02) :398-402

[4] INVOLVEMENT OF THE PPPGHR MOTIF IN T-CELL ACTIVATION VIA CD2 [J].

CHANG, HC ;

MOINGEON, P ;

PEDERSEN, R ;

LUCICH, J ;

STEBBINS, C ;

REINHERZ, EL .

JOURNAL OF EXPERIMENTAL MEDICINE, 1990, 172 (01) :351-355

[5]

CHANG JM, 1989, BLOOD, V73, P1487

[6] RECOMBINANT HUMAN INTERLEUKIN-5 IS AN EOSINOPHIL DIFFERENTIATION FACTOR BUT HAS NO ACTIVITY IN STANDARD HUMAN B-CELL GROWTH-FACTOR ASSAYS [J].

CLUTTERBUCK, E ;

SHIELDS, JG ;

GORDON, J ;

SMITH, SH ;

BOYD, A ;

CALLARD, RE ;

CAMPBELL, HD ;

YOUNG, IG ;

SANDERSON, CJ .

EUROPEAN JOURNAL OF IMMUNOLOGY, 1987, 17 (12) :1743-1750

[7]

CLUTTERBUCK EJ, 1988, BLOOD, V71, P646

[8] TRANSFORMING GROWTH FACTOR-BETA SPECIFICALLY ENHANCES IGA PRODUCTION BY LIPOPOLYSACCHARIDE-STIMULATED MURINE LYMPHOCYTES-B [J].

COFFMAN, RL ;

LEBMAN, DA ;

SHRADER, B .

JOURNAL OF EXPERIMENTAL MEDICINE, 1989, 170 (03) :1039-1044

[9] ANTIBODY TO INTERLEUKIN-5 INHIBITS HELMINTH-INDUCED EOSINOPHILIA IN MICE [J].

COFFMAN, RL ;

SEYMOUR, BWP ;

HUDAK, S ;

JACKSON, J ;

RENNICK, D .

SCIENCE, 1989, 245 (4915) :308-310

[10] CD4 T-LYMPHOCYTE ACTIVATION IN ASTHMA IS ACCOMPANIED BY INCREASED SERUM CONCENTRATIONS OF INTERLEUKIN-5 - EFFECT OF GLUCOCORTICOID THERAPY [J].

CORRIGAN, CJ ;

HACZKU, A ;

GEMOUENGESAETH, V ;

DOI, S ;

KIKUCHI, Y ;

TAKATSU, K ;

DURHAM, SR ;

KAY, AB .

AMERICAN REVIEW OF RESPIRATORY DISEASE, 1993, 147 (03) :540-547

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