IL-5 AND ITS RECEPTOR - WHICH ROLE DO THEY PLAY IN THE IMMUNE-RESPONSE

被引：54

作者：

KOIKE, M

TAKATSU, K

机构：

[1] Department of Immunology, Institute of Medical Sciences, University of Tokyo, Minato-Ku, Tokyo 108

来源：

INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY | 1994年 / 104卷 / 01期

关键词：

IL-5; RECEPTOR; B CELL; EOSINOPHIL;

D O I：

10.1159/000236702

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

IL-5 is a homodimeric glycoprotein that promotes proliferation and differentiation of activated B cells, and controls the production and functions of some other hematopoietic cells, such as Ly-1(CD5)(+) B cells, eosinophils and basophils. In humans, IL-5 acts as a differentiation and growth factor for eosinophils, and is the major cytokine involved in the production of eosinophilia. IL-5 acts on its target cells through the specific receptor that is composed of two polypeptide chains, a and b. The alpha-chain is unique to IL-5, while the beta-chain is common to IL-5 receptor, IL-3 receptor and granulocyte-macrophage colony stimulating factor (GM-CSF) receptor.

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页码：1 / 9

页数：9

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