SINGLE-CENTER EXPERIENCE WITH PRIMARY ORTHOTOPIC LIVER-TRANSPLANTATION WITH FK-506 IMMUNOSUPPRESSION

被引：62

作者：

TODO, S ^{[1
]}

FUNG, JJ ^{[1
]}

STARZL, TE ^{[1
]}

TZAKIS, A ^{[1
]}

DOYLE, H ^{[1
]}

ABUELMAGD, K ^{[1
]}

JAIN, A ^{[1
]}

SELBY, R ^{[1
]}

BRONSTHER, O ^{[1
]}

MARSH, W ^{[1
]}

RAMOS, H ^{[1
]}

REYES, J ^{[1
]}

GAYOWSKI, T ^{[1
]}

CASAVILLA, A ^{[1
]}

DODSON, F ^{[1
]}

FURUKAWA, H ^{[1
]}

MARINO, I ^{[1
]}

PINNA, A ^{[1
]}

NOUR, B ^{[1
]}

JABBOUR, N ^{[1
]}

MAZARIEGOS, G ^{[1
]}

MCMICHAEL, J ^{[1
]}

KUSNE, S ^{[1
]}

VENKATARAMANAN, R ^{[1
]}

WARTY, V ^{[1
]}

MURASE, N ^{[1
]}

DEMETRIS, AJ ^{[1
]}

IWATSUKI, S ^{[1
]}

机构：

[1] UNIV PITTSBURGH, MED CTR, PITTSBURGH TRANSPLANT INST, DEPT SURG, PITTSBURGH, PA 15213 USA

来源：

ANNALS OF SURGERY | 1994年 / 220卷 / 03期

关键词：

D O I：

10.1097/00000658-199409000-00006

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

Objective The efficacy for primary orthotopic liver transplantation of a new immunosuppressive agent, FK 506 (tacrolimus, Prograf, Fujisawa USA, Deerfield, IL), was determined. Summary Background Data After 3 years of preclinical research, a clinical trial of FK 506 for orthotopic liver transplantation was begun in February 1989, first as a rescue therapy for patients with intractable rejection with conventional immunosuppression, then as a primary drug. Methods Between August 1989 and December 1993, 1391 recipients (1188 adult and 203 pediatric) of primary liver allografts were treated with FK 506 from the outset. Results from these patients were analyzed and compared with those of 1212 historical control patients (971 adult and 241 pediatric) given cyclosporine-based immunosuppression. Results Actuarial survival at 4 years was 86.2% with FK 506 versus 65.5% with cyclosporine in the pediatric patients (p < 0.0000) and 71.4% versus 65.5% in the adults (p < 0.0005). The need for retransplantation was reduced significantly for FK 506 patients. Four-year graft survival was 77.0% with FK 506 versus 48.4% with cyclosporine in the pediatric patients (p < 0.0000), and 61.9% with FK 506 versus 51.4% with cyclosporine in the adult recipients (p < 0.0000). Regression analysis revealed that reductions in mortality or graft loss from uncontrollable rejection, sepsis, technical failure, and recurrent original liver disease were responsible for the improved results with FK 506 therapy. Conclusions FK 506 is a potent and superior immunosuppressive agent for orthotopic liver transplantation.

引用

页码：297 / 309

页数：13

共 53 条

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