Okadaic acid protects human neuroblastoma SH-SY5Y cells from 1-methyl-4-phenylpyridinium ion-induced apoptosis

被引：27

作者：

Ahn, Kook-Hee ^{[1
]}

Kim, Young-Sun ^{[1
]}

Kim, Seon-Ye ^{[1
]}

Huh, Youngbuhm ^{[1
]}

Park, Chan ^{[1
]}

Jeong, Loo-Won ^{[1
]}

机构：

[1] Kyung Hee Univ, Sch Med, Inst Biomed Sci, Dept Anat & Neurobiol, Seoul 130701, South Korea

来源：

NEUROSCIENCE LETTERS | 2009年 / 449卷 / 02期

关键词：

Okadaic acid; MPP+; Apoptosis; ROS; Parkinson's disease; PARKINSONS-DISEASE; OXIDATIVE STRESS; CELLULAR-MODELS; MOUSE SKIN; KAPPA-B; EXPRESSION; MPP+; PHOSPHATASE-1; MITOCHONDRIA; INHIBITION;

D O I：

10.1016/j.neulet.2008.10.103

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

1-Methyl-4-phenylpyridinium ion (MPP+) has been shown to selectively inhibit mitochondrial function and induce a parkinsonism-like syndrome. MPP+ stimulates the production of reactive oxygen species (ROS) and induces cell death in vitro. In this study, we investigated the protective effects of okadaic acid on MPP+-induced cell death in SH-SY5Y neuroblastoma cells. We found that MPP+-induced apoptosis and -ROS generation were blocked by okadaic acid, MPP+-mediated activation of AKT was also inhibited by okadaic acid. Taken together, these results demonstrate that okadaic acid protects against MPP+-induced apoptosis by blocking ROS stimulation and ROS-mediated signaling pathways in SH-SY5Y cells. These data indicated that okadaic acid could provide a therapeutic strategy for the treatment of neurodegenerative diseases including Parkinson's disease. Crown Copyright (C) 2008 Published by Elsevier Ireland Ltd. All rights reserved.

引用

页码：93 / 97

页数：5

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