ZINC-DEFICIENCY AND CORTICOSTEROIDS IN THE PATHOGENESIS OF ALCOHOLIC BRAIN-DYSFUNCTION - A REVIEW

被引：28

作者：

MENZANO, E

CARLEN, PL

机构：

[1] TORONTO HOSP, RES INST, PLAYFAIR NEUROSCI UNIT, NEUROPHARMACOL PROGRAM, TORONTO M5T 2S8, ON, CANADA

[2] UNIV TORONTO, ADDICT RES FDN, TORONTO, ON, CANADA

来源：

ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH | 1994年 / 18卷 / 04期

关键词：

ALCOHOLISM; BRAIN DYSFUNCTION; ZN DEFICIENCY; CORTICOSTEROIDS; FREE RADICALS;

D O I：

10.1111/j.1530-0277.1994.tb00057.x

中图分类号：

R194 [卫生标准、卫生检查、医药管理];

学科分类号：

摘要：

Chronic alcoholism is associated with hypercortisolemia and low serum zinc (Zn). Hypercortisolemia could be responsible for alcoholic cerebral atrophy and is also associated with enhanced NMDA neurotoxicity. It is hypothesized that low brain Zn, noted in chronic alcoholics, enhances NMDA excitotoxicity and ethanol withdrawal seizure susceptibility. Also, Zn deficiency can produce neuronal damage through increased free radical formation. Clinically, Zn replacement therapy may be a rational approach to the treatment of alcohol withdrawal seizures and alcohol-related brain dysfunction.

引用

页码：895 / 901

页数：7

共 116 条

[11] PARTIALLY REVERSIBLE CEREBRAL ATROPHY AND FUNCTIONAL IMPROVEMENT IN RECENTLY ABSTINENT ALCOHOLICS [J].