THE TOXICITY OF DAILY INHALED AMPHOTERICIN-B

被引：38

作者：

GRYN, J ^{[1
]}

GOLDBERG, J ^{[1
]}

JOHNSON, E ^{[1
]}

SIEGEL, J ^{[1
]}

INZERILLO, J ^{[1
]}

机构：

[1] COOPER UNIV MED CTR, ROBERT WOOD JOHNSON SCH MED, DEPT MED, CAMDEN, NJ USA

来源：

AMERICAN JOURNAL OF CLINICAL ONCOLOGY-CANCER CLINICAL TRIALS | 1993年 / 16卷 / 01期

关键词：

FUNGAL PNEUMONIA; AMPHOTERICIN-B; INHALATION THERAPY; NEUTROPENIA;

D O I：

10.1097/00000421-199302000-00011

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Inhaled amphotericin was administered to 29 patients with prolonged neutropenia and toxicity was analyzed. Treatment consisted of 30 mg of amphotericin B administered by nebulizer once daily via either a hand-held nebulizer or face mask. The mean duration of treatment was 16 days. Toxicity was minimal and patient had significant toxic reaction to the inhaled medication. This study documents that nebulized amphotericin B has less than 10% incidence of severe toxicity with 95% confidence level. Guidelines for future trials and use are suggested.

引用

页码：43 / 46

页数：4

共 24 条

[1]

BAILEY EM, 1990, PHARMACOTHERAPY, V10, P146

[2] IMPROVED APPROXIMATE FORMULA FOR CALCULATING SAMPLE SIZES FOR COMPARING 2 BINOMIAL DISTRIBUTIONS [J].

CASAGRANDE, JT ;

PIKE, MC ;

SMITH, PG .

BIOMETRICS, 1978, 34 (03) :483-486

[3] TISSUE CONCENTRATIONS AND BIOACTIVITY OF AMPHOTERICIN-B IN CANCER-PATIENTS TREATED WITH AMPHOTERICIN-B-DEOXYCHOLATE [J].

COLLETTE, N ;

VANDERAUWERA, P ;

LOPEZ, AP ;

HEYMANS, C ;

MEUNIER, F .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1989, 33 (03) :362-368

[4]

CONNEALLY E, 1990, BONE MARROW TRANSPL, V5, P403

[5] FUNGAL-INFECTIONS IN PATIENTS WITH ACUTE-LEUKEMIA [J].

DEGREGORIO, MW ;

LEE, WMF ;

LINKER, CA ;

JACOBS, RA ;

RIES, CA .

AMERICAN JOURNAL OF MEDICINE, 1982, 73 (04) :543-548

[6] PULMONARY CONSIDERATIONS OF ORGAN-TRANSPLANTATION .2. [J].

ETTINGER, NA ;

TRULOCK, EP .

AMERICAN REVIEW OF RESPIRATORY DISEASE, 1991, 144 (01) :213-223

[7] PROLONGED GRANULOCYTOPENIA - THE MAJOR RISK FACTOR FOR INVASIVE PULMONARY ASPERGILLOSIS IN PATIENTS WITH ACUTE-LEUKEMIA [J].

GERSON, SL ;

TALBOT, GH ;

HURWITZ, S ;

STROM, BL ;

LUSK, EJ ;

CASSILETH, PA .

ANNALS OF INTERNAL MEDICINE, 1984, 100 (03) :345-351

[8] NEW HOSPITAL HAZARDS - HOW TO PROTECT YOURSELF [J].

JACOBSON, E .

AMERICAN JOURNAL OF NURSING, 1990, 90 (02) :36-+

[9]

JEFFERY GM, 1991, AM J MED, V90, P685, DOI 10.1016/S0002-9343(05)80056-7

[10] LIPOSOMAL AMPHOTERICIN-B FOR THE TREATMENT OF SYSTEMIC FUNGAL-INFECTIONS IN PATIENTS WITH CANCER - A PRELIMINARY-STUDY [J].

LOPEZBERESTEIN, G ;

FAINSTEIN, V ;

HOPFER, R ;

MEHTA, K ;

SULLIVAN, MP ;

KEATING, M ;

ROSENBLUM, MG ;

MEHTA, R ;

LUNA, M ;

HERSH, EM ;

REUBEN, J ;

JULIANO, RL ;

BODEY, GP .

JOURNAL OF INFECTIOUS DISEASES, 1985, 151 (04) :704-710

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