THE TOXICITY OF DAILY INHALED AMPHOTERICIN-B

被引：38

作者：

GRYN, J ^{[1
]}

GOLDBERG, J ^{[1
]}

JOHNSON, E ^{[1
]}

SIEGEL, J ^{[1
]}

INZERILLO, J ^{[1
]}

机构：

[1] COOPER UNIV MED CTR, ROBERT WOOD JOHNSON SCH MED, DEPT MED, CAMDEN, NJ USA

来源：

AMERICAN JOURNAL OF CLINICAL ONCOLOGY-CANCER CLINICAL TRIALS | 1993年 / 16卷 / 01期

关键词：

FUNGAL PNEUMONIA; AMPHOTERICIN-B; INHALATION THERAPY; NEUTROPENIA;

D O I：

10.1097/00000421-199302000-00011

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Inhaled amphotericin was administered to 29 patients with prolonged neutropenia and toxicity was analyzed. Treatment consisted of 30 mg of amphotericin B administered by nebulizer once daily via either a hand-held nebulizer or face mask. The mean duration of treatment was 16 days. Toxicity was minimal and patient had significant toxic reaction to the inhaled medication. This study documents that nebulized amphotericin B has less than 10% incidence of severe toxicity with 95% confidence level. Guidelines for future trials and use are suggested.

引用

页码：43 / 46

页数：4

共 24 条

[21] SUBCLINICAL PULMONARY-FUNCTION DEFECTS FOLLOWING AUTOLOGOUS AND ALLOGENEIC BONE-MARROW TRANSPLANTATION - RELATIONSHIP TO TOTAL-BODY IRRADIATION AND GRAFT-VERSUS-HOST DISEASE [J].

TAIT, RC ;

BURNETT, AK ;

ROBERTSON, AG ;

MCNEE, S ;

RIYAMI, BMS ;

CARTER, R ;

STEVENSON, RD .

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 1991, 20 (06) :1219-1227

[22]

Walsh T J, 1990, Semin Respir Infect, V5, P111

[23] ITRACONAZOLE AND FLUCONAZOLE - NEW DRUGS FOR DEEP FUNGAL INFECTION [J].

WARNOCK, DW .

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 1989, 24 (03) :275-277

[24]

1989, MMWR, V38, P256

← 1 2 3 →