DNA repair in humans

被引：190

作者：

Sancar, A

机构：

[1] Department of Biochemistry, University of North Carolina, School of Medicine, Chapel Hill

来源：

ANNUAL REVIEW OF GENETICS | 1995年 / 29卷

关键词：

repair enzymes; transcription-repair coupling; cell cycle and repair; cellular response to damage; damage and cancer; repair and chemotherapy;

D O I：

10.1146/annurev.ge.29.120195.000441

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

DNA repair is an important molecular defense system against agents that cause cancer, degenerative diseases, and aging. Several repair systems in humans protect the genome by repairing modified bases, DNA adducts, crosslinks, and double strand breaks. These repair systems, base excision, nucleotide excision, and recombination, are intimately connected to transcription and to cell cycle checkpoints. In addition, genotoxic stress induces a set of cellular reactions mediated by the p53 tumor suppressor and the Ras oncogene. These genotoxic response reactions may help the cell survive or enter apoptosis. Damage-response reactions may be utilized as targets of anticancer chemotherapy.

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收藏

页码：69 / 105

页数：37

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