DELETION OF CHROMOSOME-13 IN OSTEOSARCOMA SECONDARY TO IRRADIATION

被引：18

作者：

OZISIK, YY

MELONI, AM

ZALUPSKI, MM

RYAN, JR

QURESHI, F

SANDBERG, AA

机构：

[1] GENETRIX INC,SCOTTSDALE,AZ 85251

[2] WAYNE STATE UNIV,DEPT MED,DETROIT,MI 48202

[3] WAYNE STATE UNIV,DEPT PATHOL,DETROIT,MI 48202

[4] WAYNE STATE UNIV,DEPT ORTHOPED SURG,DETROIT,MI 48202

来源：

CANCER GENETICS AND CYTOGENETICS | 1993年 / 69卷 / 01期

关键词：

D O I：

10.1016/0165-4608(93)90109-Y

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The cytogenetic analysis of a radiation-induced osteosarcoma in a 31-year-old male is presented. Complex karyotypic changes with numerical and structural abnormalities, including a del(13)(q12.3q21.1), were observed. This deletion may indicate that loss of RB1 gene (locus in 13q14) may be involved in the development of radiation-induced osteosarcoma.

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页码：35 / 37

页数：3

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