PLASMINOGEN-ACTIVATOR INHIBITOR-1 IN THE CEREBROSPINAL-FLUID AS AN INDEX OF NEUROLOGICAL DISEASE

被引:51
作者
SUTTON, R
KEOHANE, ME
VANDENBERG, SR
GONIAS, SL
机构
[1] UNIV VIRGINIA,HLTH SCI CTR,DEPT PATHOL,CHARLOTTESVILLE,VA 22908
[2] UNIV VIRGINIA,HLTH SCI CTR,DEPT BIOCHEM,CHARLOTTESVILLE,VA 22908
[3] HENRY FORD HOSP,DEPT PATHOL,DETROIT,MI 48202
关键词
PLASMINOGEN ACTIVATOR INHIBITOR-1; CEREBROSPINAL FLUID; SERPINS; NEUROLOGICAL DISEASE;
D O I
10.1097/00001721-199404000-00002
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Plasminogen activator inhibitor-1 (PAI-1) is a serpin proteinase inhibitor which regulates fibrinolysis and the proteinase cascade of tumour invasion. In this study, PAI-1 was identified in the cerebrospinal fluid (CSF) from patients without neurological disease and patients with various neurological disorders. The mean level of PAI-1 in the CSF of 28 patients without central nervous system (CNS) disease was 0.28 +/- 0.03 (SEM) ng/ml. CSF PAI-1 was significantly increased in the following diagnostic categories: dementia (Alzheimer's disease), cerebral infarction, CNS infection, alcohol withdrawal seizures and CNS neoplasia. In all these disorders, with the exception of CNS infection, PAI-1 was also increased as a fraction of total CSF protein. CSF PAI-1 was not increased in patients with hydrocephalus or idiopathic seizure disorders. Complementary plasma samples were available for 18 of the 128 CSF specimens studied. For these cases, there was no correlation between plasma PAI-1 and CSF PAI-1 levels. PAI-I may represent a non-specific marker of disease in the central nervous system.
引用
收藏
页码:167 / 171
页数:5
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