NUCLEAR MAGNETIC-RESONANCE STUDY OF THE SOLUTION CONFORMATION OF ADENINE MONO-NUCLEOTIDES USING THE LANTHANIDE PROBE METHOD

被引：15

作者：

GERALDES, CFGC ^{[1
]}

机构：

[1] INORGAN CHEM LAB,OXFORD OX1 3QR,ENGLAND

来源：

JOURNAL OF MAGNETIC RESONANCE | 1979年 / 36卷 / 01期

关键词：

D O I：

10.1016/0022-2364(79)90218-X

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

The use of lanthanide ions as NMR shift and relaxation probes has enabled the determination of the conformations of adenosine 2′-monophosphate and adenosine 3′-monophosphate in aqueous solution. These nucleotides are much more flexible than the corresponding 5′-mononucleotide. The interpretation of the lanthanide data, based on mixing different conformations in fast exchange within the NMR time scale, agrees well with conformational evidence for the metal-free systems, obtained from independent NMR methods. © 1979.

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页码：89 / 98

页数：10

相关论文

共 23 条

[1]

ALDERFER JL, 1976, BIOPHYS J, V16, P110

[2] CONFORMATIONAL-ANALYSIS OF SUGAR RING IN NUCLEOSIDES AND NUCLEOTIDES - NEW DESCRIPTION USING CONCEPT OF PSEUDOROTATION [J].

ALTONA, C ;

SUNDARALINGAM, M .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1972, 94 (23) :8205-+

[3] CONFORMATIONAL-ANALYSIS OF SUGAR RING IN NUCLEOSIDES AND NUCLEOTIDES - IMPROVED METHOD FOR INTERPRETATION OF PROTON MAGNETIC-RESONANCE COUPLING-CONSTANTS [J].

ALTONA, C ;

SUNDARALINGAM, M .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1973, 95 (07) :2333-2344

[4] QUANTITATIVE-DETERMINATION OF CONFORMATIONS OF FLEXIBLE MOLECULES IN SOLUTION USING LANTHANIDE IONS AS NUCLEAR MAGNETIC-RESONANCE PROBES - APPLICATION TO ADENOSINE-5'-MONOPHOSPHATE [J].

BARRY, CD ;

GLASEL, JA ;

WILLIAMS, RJP ;

XAVIER, AV .

JOURNAL OF MOLECULAR BIOLOGY, 1974, 84 (04) :471-490

[5] QUANTITATIVE DETERMINATION OF MONONUCLEOTIDE CONFORMATIONS IN SOLUTION USING LANTHANIDE ION SHIFT AND BROADENING NMR PROBES [J].

BARRY, CD ;

NORTH, ACT ;

GLASEL, JA ;

WILLIAMS, RJP ;

XAVIER, AV .

NATURE, 1971, 232 (5308) :236-+

[6] NUCLEAR MAGNETIC-RESONANCE INVESTIGATION OF CONFORMATION OF NICOTINAMIDE MONONUCLEOTIDE IN AQUEOUS-SOLUTION [J].

BIRDSALL, B ;

BIRDSALL, NJM ;

FEENEY, J ;

THORNTON, J .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1975, 97 (10) :2845-2850

[7] NUCLEAR MAGNETIC-RESONANCE SHIFTS IN SOLUTION DUE TO LANTHANIDE IONS [J].

BLEANEY, B .

JOURNAL OF MAGNETIC RESONANCE, 1972, 8 (01) :91-&

[8] PSEUDO-CONTACT CONTRIBUTIONS TO LANTHANIDE-INDUCED NUCLEAR MAGNETIC-RESONANCE SHIFTS [J].

BRIGGS, JM ;

SALES, KD ;

MOSS, GP ;

RANDALL, EW .

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, 1972, (21) :1180-&

[9] P-31 FOURIER-TRANSFORM NUCLEAR MAGNETIC-RESONANCE STUDY OF MONONUCLEOTIDES AND DINUCLEOTIDES .2. COUPLING-CONSTANTS [J].

COZZONE, PJ ;

JARDETZKY, O .

BIOCHEMISTRY, 1976, 15 (22) :4860-4865

[10] NUCLEAR MAGNETIC-RESONANCE STUDIES OF 2'-RIBONUCLEOTIDE AND 3'-RIBONUCLEOTIDE STRUCTURES IN SOLUTION [J].

DAVIES, DB ;

DANYLUK, SS .

BIOCHEMISTRY, 1975, 14 (03) :543-554