SEASONAL AND SEX-LINKED VARIATIONS IN HEPATIC AND EXTRAHEPATIC BIOTRANSFORMATION ACTIVITIES IN STRIPED MULLET (MULLUS-BARBATUS)

被引：35

作者：

MATHIEU, A ^{[1
]}

LEMAIRE, P ^{[1
]}

CARRIERE, S ^{[1
]}

DRAI, P ^{[1
]}

GIUDICELLI, J ^{[1
]}

LAFAURIE, M ^{[1
]}

机构：

[1] FAC MED NICE,BIOCHIM LAB,F-06034 NICE,FRANCE

来源：

ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY | 1991年 / 22卷 / 01期

关键词：

D O I：

10.1016/0147-6513(91)90046-R

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

Microsomal cytochrome P450 content, NADPH-cytochrome c reductase, and phase I (ethoxycoumarin and ethoxyresorufin O-dealkylases) and phase II (glutathione S-transferase and UDP-glucuronyltransferase) activities were studied in the liver and intestine of the striped mullet (Mullus barbatus) for 8 months (before and during sexual maturation). Biotransformation activities were much lower in extrahepatic tissues than the corresponding activities in the liver. Intestinal and hepatic biotransformation activities presented similar seasonal fluctuations: Phase I activity increased from October to February (during water cooling) and generally decreased before spawning; Phase II activity was not greatly different. Moreover, NADPH-cytochrome c reductase, ethoxyresorufin O-dealkylase, and glutathione S-transferase activities were measured in the kidney during the sexual maturation period. Renal phase I and phase II activities showed very little fluctuation during the 5 months studied. Cytochrome P450 and ethoxycoumarin and ethoxyresorufin O-dealkylases exhibited sex-linked differences during sexual maturation, whatever the tissue: in the liver the values are higher in male fish, whereas in the intestine and kidney they are lower. © 1991.

引用

页码：45 / 57

页数：13

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