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RECOMBINANT HUMAN NERVE GROWTH-FACTOR PREVENTS RETROGRADE DEGENERATION OF AXOTOMIZED BASAL FOREBRAIN CHOLINERGIC NEURONS IN THE RAT
被引:84
作者
:
KOLIATSOS, VE
论文数:
0
引用数:
0
h-index:
0
机构:
JOHNS HOPKINS UNIV,SCH MED,DEPT NEUROL,BALTIMORE,MD 21205
KOLIATSOS, VE
APPLEGATE, MD
论文数:
0
引用数:
0
h-index:
0
机构:
JOHNS HOPKINS UNIV,SCH MED,DEPT NEUROL,BALTIMORE,MD 21205
APPLEGATE, MD
KNUSEL, B
论文数:
0
引用数:
0
h-index:
0
机构:
JOHNS HOPKINS UNIV,SCH MED,DEPT NEUROL,BALTIMORE,MD 21205
KNUSEL, B
JUNARD, EO
论文数:
0
引用数:
0
h-index:
0
机构:
JOHNS HOPKINS UNIV,SCH MED,DEPT NEUROL,BALTIMORE,MD 21205
JUNARD, EO
BURTON, LE
论文数:
0
引用数:
0
h-index:
0
机构:
JOHNS HOPKINS UNIV,SCH MED,DEPT NEUROL,BALTIMORE,MD 21205
BURTON, LE
MOBLEY, WC
论文数:
0
引用数:
0
h-index:
0
机构:
JOHNS HOPKINS UNIV,SCH MED,DEPT NEUROL,BALTIMORE,MD 21205
MOBLEY, WC
HEFTI, FF
论文数:
0
引用数:
0
h-index:
0
机构:
JOHNS HOPKINS UNIV,SCH MED,DEPT NEUROL,BALTIMORE,MD 21205
HEFTI, FF
PRICE, DL
论文数:
0
引用数:
0
h-index:
0
机构:
JOHNS HOPKINS UNIV,SCH MED,DEPT NEUROL,BALTIMORE,MD 21205
PRICE, DL
机构
:
[1]
JOHNS HOPKINS UNIV,SCH MED,DEPT NEUROL,BALTIMORE,MD 21205
[2]
JOHNS HOPKINS UNIV,SCH MED,DEPT NEUROSCI,BALTIMORE,MD 21205
[3]
JOHNS HOPKINS UNIV,SCH MED,NEUROPATHOL LAB,BALTIMORE,MD 21205
[4]
UNIV SO CALIF,ETHEL PERCY ANDRUS GERONTOL CTR,LOS ANGELES,CA 90089
[5]
GENENTECH INC,S SAN FRANCISCO,CA
[6]
UNIV CALIF SAN FRANCISCO,DEPT NEUROL,SAN FRANCISCO,CA 94143
来源
:
EXPERIMENTAL NEUROLOGY
|
1991年
/ 112卷
/ 02期
关键词
:
D O I
:
10.1016/0014-4886(91)90066-L
中图分类号
:
Q189 [神经科学];
学科分类号
:
071006 ;
摘要
:
Cholinergic neurons in the basal forebrain magnocellular complex (BFMC) respond to nerve growth factor (NGF) during development and in adult life, and it has been suggested that the administration of NGF might ameliorate some of the abnormalities that occur in neurological disorders associated with degeneration of this population of neurons. A prerequisite for the introduction of NGF in clinical trials is the availability of active recombinant human NGF (rhNGF). The present investigation was designed to test, in vivo, the efficacy of a preparation of rhNGF. Axons of cholinergic neurons of the BFMC in the rat were transected in the fimbria-fornix; this manipulation alters the phenotype and, eventually, causes retrograde degeneration of these neurons. Our investigation utilized two lesion paradigms (resection and partial transection of fibers in the fimbria-fornix), two different strains of rats, and two delivery systems. Following lesions, animals were allowed to survive for 2 weeks, during which time one group received intraventricular mouse NGF (mNGF), a second group received rhNGF, and a third group received vehicle alone. In animals receiving vehicle, there was a significant reduction in the number (resection: 70%; transection: 50%) and some reduction in size of choline acetyltransferase- or NGF receptor-immunoreactive cell bodies within the medial septal nucleus ipsilateral to the lesion. Treatment with either mNGF or rhNGF completely prevented these alterations in the number and size of cholinergic neurons. The rhNGF was shown to be equivalent in efficacy with mNGF. Thus, rhNGF is effective in preventing axotomy-induced degenerative changes in cholinergic neurons of the BFMC. Our results, taken together with the in vitro effects of rhNGF (42), indicate that an active rhNGF is now available for further in vivo studies in rodents and primates with experimentally induced or age-associated lesions of basal forebrain cholinergic neurons. These investigations provide essential information for the consideration of future utilization of rhNGF for treatment of human neurological disorders, including Alzheimer's disease. © 1991.
引用
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页码:161 / 173
页数:13
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MT SINAI SCH MED,BRONX,NY 10468
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HARVARD UNIV,DIV NEUROSCI & BEHAV NEUROL,BOSTON,MA 02215
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WEINER, WJ
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HARVARD UNIV,DIV NEUROSCI & BEHAV NEUROL,BOSTON,MA 02215
WEINER, WJ
MASH, DC
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HARVARD UNIV,DIV NEUROSCI & BEHAV NEUROL,BOSTON,MA 02215
HARVARD UNIV,DIV NEUROSCI & BEHAV NEUROL,BOSTON,MA 02215
MASH, DC
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HEFTI F, 1986, J NEUROSCI, V6, P2155
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CHRONIC INTRAVENTRICULAR-INJECTIONS OF NERVE GROWTH-FACTOR ELEVATE HIPPOCAMPAL CHOLINE-ACETYLTRANSFERASE ACTIVITY IN ADULT-RATS WITH PARTIAL SEPTO-HIPPOCAMPAL LESIONS
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DRAVID, A
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DRAVID, A
HARTIKKA, J
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HARTIKKA, J
[J].
BRAIN RESEARCH,
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NGF INDUCTION OF NGF RECEPTOR GENE-EXPRESSION AND CHOLINERGIC NEURONAL HYPERTROPHY WITHIN THE BASAL FOREBRAIN OF THE ADULT-RAT
HIGGINS, GA
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0
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0
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UNIV CALIF SAN DIEGO, DEPT NEUROSCI, LA JOLLA, CA 92093 USA
UNIV CALIF SAN DIEGO, DEPT NEUROSCI, LA JOLLA, CA 92093 USA
HIGGINS, GA
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UNIV CALIF SAN DIEGO, DEPT NEUROSCI, LA JOLLA, CA 92093 USA
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[J].
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256
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CHRISTOPHER CTR PARKINSONS RES,DIV MORPHOL STUDIES,INST BIOGERONT RES,SUN CITY,AZ 85351
CHRISTOPHER CTR PARKINSONS RES,DIV MORPHOL STUDIES,INST BIOGERONT RES,SUN CITY,AZ 85351
HIGGINS, GA
MUFSON, EJ
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h-index:
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CHRISTOPHER CTR PARKINSONS RES,DIV MORPHOL STUDIES,INST BIOGERONT RES,SUN CITY,AZ 85351
CHRISTOPHER CTR PARKINSONS RES,DIV MORPHOL STUDIES,INST BIOGERONT RES,SUN CITY,AZ 85351
MUFSON, EJ
[J].
EXPERIMENTAL NEUROLOGY,
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ISAACSON L G, 1989, Society for Neuroscience Abstracts, V15, P91
[40]
KITT C A, 1988, Society for Neuroscience Abstracts, V14, P631
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3
4
5
6
7
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共 86 条
[31]
DELAYED TREATMENT WITH NERVE GROWTH-FACTOR REVERSES THE APPARENT LOSS OF CHOLINERGIC NEURONS AFTER ACUTE BRAIN-DAMAGE
HAGG, T
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HAGG, T
MANTHORPE, M
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VAHLSING, HL
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VARON, S
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0
引用数:
0
h-index:
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[J].
EXPERIMENTAL NEUROLOGY,
1988,
101
(02)
: 303
-
312
[32]
PARTIAL REVERSAL OF LESION-INDUCED DEFICITS IN CORTICAL CHOLINERGIC MARKERS BY NERVE GROWTH-FACTOR
HAROUTUNIAN, V
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引用数:
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h-index:
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MT SINAI SCH MED,BRONX,NY 10468
MT SINAI SCH MED,BRONX,NY 10468
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KANOF, PD
论文数:
0
引用数:
0
h-index:
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MT SINAI SCH MED,BRONX,NY 10468
MT SINAI SCH MED,BRONX,NY 10468
KANOF, PD
DAVIS, KL
论文数:
0
引用数:
0
h-index:
0
机构:
MT SINAI SCH MED,BRONX,NY 10468
MT SINAI SCH MED,BRONX,NY 10468
DAVIS, KL
[J].
BRAIN RESEARCH,
1986,
386
(1-2)
: 397
-
399
[33]
LOCALIZATION OF NERVE GROWTH-FACTOR RECEPTORS IN CHOLINERGIC NEURONS OF THE HUMAN BASAL FOREBRAIN
HEFTI, F
论文数:
0
引用数:
0
h-index:
0
机构:
HARVARD UNIV,DIV NEUROSCI & BEHAV NEUROL,BOSTON,MA 02215
HARVARD UNIV,DIV NEUROSCI & BEHAV NEUROL,BOSTON,MA 02215
HEFTI, F
论文数:
引用数:
h-index:
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HARTIKKA, J
SALVATIERRA, A
论文数:
0
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h-index:
0
机构:
HARVARD UNIV,DIV NEUROSCI & BEHAV NEUROL,BOSTON,MA 02215
HARVARD UNIV,DIV NEUROSCI & BEHAV NEUROL,BOSTON,MA 02215
SALVATIERRA, A
WEINER, WJ
论文数:
0
引用数:
0
h-index:
0
机构:
HARVARD UNIV,DIV NEUROSCI & BEHAV NEUROL,BOSTON,MA 02215
HARVARD UNIV,DIV NEUROSCI & BEHAV NEUROL,BOSTON,MA 02215
WEINER, WJ
MASH, DC
论文数:
0
引用数:
0
h-index:
0
机构:
HARVARD UNIV,DIV NEUROSCI & BEHAV NEUROL,BOSTON,MA 02215
HARVARD UNIV,DIV NEUROSCI & BEHAV NEUROL,BOSTON,MA 02215
MASH, DC
[J].
NEUROSCIENCE LETTERS,
1986,
69
(01)
: 37
-
41
[34]
HEFTI F, 1986, J NEUROSCI, V6, P2155
[35]
CHRONIC INTRAVENTRICULAR-INJECTIONS OF NERVE GROWTH-FACTOR ELEVATE HIPPOCAMPAL CHOLINE-ACETYLTRANSFERASE ACTIVITY IN ADULT-RATS WITH PARTIAL SEPTO-HIPPOCAMPAL LESIONS
HEFTI, F
论文数:
0
引用数:
0
h-index:
0
HEFTI, F
DRAVID, A
论文数:
0
引用数:
0
h-index:
0
DRAVID, A
HARTIKKA, J
论文数:
0
引用数:
0
h-index:
0
HARTIKKA, J
[J].
BRAIN RESEARCH,
1984,
293
(02)
: 305
-
311
[36]
HEFTI F, 1988, NEUROBIOLOGY AMINO A, P127
[37]
NGF INDUCTION OF NGF RECEPTOR GENE-EXPRESSION AND CHOLINERGIC NEURONAL HYPERTROPHY WITHIN THE BASAL FOREBRAIN OF THE ADULT-RAT
HIGGINS, GA
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV CALIF SAN DIEGO, DEPT NEUROSCI, LA JOLLA, CA 92093 USA
UNIV CALIF SAN DIEGO, DEPT NEUROSCI, LA JOLLA, CA 92093 USA
HIGGINS, GA
KOH, SY
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV CALIF SAN DIEGO, DEPT NEUROSCI, LA JOLLA, CA 92093 USA
UNIV CALIF SAN DIEGO, DEPT NEUROSCI, LA JOLLA, CA 92093 USA
KOH, SY
CHEN, KS
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV CALIF SAN DIEGO, DEPT NEUROSCI, LA JOLLA, CA 92093 USA
UNIV CALIF SAN DIEGO, DEPT NEUROSCI, LA JOLLA, CA 92093 USA
CHEN, KS
GAGE, FH
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV CALIF SAN DIEGO, DEPT NEUROSCI, LA JOLLA, CA 92093 USA
UNIV CALIF SAN DIEGO, DEPT NEUROSCI, LA JOLLA, CA 92093 USA
GAGE, FH
[J].
NEURON,
1989,
3
(02)
: 247
-
256
[38]
NGF RECEPTOR GENE-EXPRESSION IS DECREASED IN THE NUCLEUS BASALIS IN ALZHEIMERS-DISEASE
HIGGINS, GA
论文数:
0
引用数:
0
h-index:
0
机构:
CHRISTOPHER CTR PARKINSONS RES,DIV MORPHOL STUDIES,INST BIOGERONT RES,SUN CITY,AZ 85351
CHRISTOPHER CTR PARKINSONS RES,DIV MORPHOL STUDIES,INST BIOGERONT RES,SUN CITY,AZ 85351
HIGGINS, GA
MUFSON, EJ
论文数:
0
引用数:
0
h-index:
0
机构:
CHRISTOPHER CTR PARKINSONS RES,DIV MORPHOL STUDIES,INST BIOGERONT RES,SUN CITY,AZ 85351
CHRISTOPHER CTR PARKINSONS RES,DIV MORPHOL STUDIES,INST BIOGERONT RES,SUN CITY,AZ 85351
MUFSON, EJ
[J].
EXPERIMENTAL NEUROLOGY,
1989,
106
(03)
: 222
-
236
[39]
ISAACSON L G, 1989, Society for Neuroscience Abstracts, V15, P91
[40]
KITT C A, 1988, Society for Neuroscience Abstracts, V14, P631
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