CYTOCHROME-B561, ASCORBIC-ACID, AND TRANSMEMBRANE ELECTRON-TRANSFER

被引：34

作者：

FLEMING, PJ

KENT, UM

机构：

[1] Dept. of Biochem. and Molec. Biology, Georgetown University Medical Center, Washington, DC

[2] Dept. of Biochem. and Molec. Biology, 353 Basic Science Building, Georgetown University Medical Center, Washington

来源：

AMERICAN JOURNAL OF CLINICAL NUTRITION | 1991年 / 54卷 / 06期

关键词：

CYTOCHROME; ELECTRON TRANSFER; ASCORBIC ACID; SECRETORY VESICLES; TRANSMEMBRANE;

D O I：

10.1093/ajcn/54.6.1173s

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

Cytochrome b561 is a transmembrane protein unique to neuroendocrine secretory vesicles. It acts as an electron channel and mediates equilibration of ascorbate-semidehydroascorbate inside the secretory vesicle with the ascorbate redox pair in the cytoplasm. The role for this function is to regenerate ascorbate inside the secretory vesicle for use by monooxygenases. Elucidation of the structure and mechanism of redox activity of cytochrome b561 may demonstrate paradigms for other ascorbate-utilizing enzymes as well as provide insights into long-range biological electron transfer.

引用

页码：S1173 / S1178

页数：6

共 33 条

[21] MENNITI FS, 1986, J BIOL CHEM, V261, P6901
[22] MYER YP, 1984, J BIOL CHEM, V259, P8144
[23] NJUS D, 1983, J BIOL CHEM, V258, P27
[24] THE STRUCTURE OF CYTOCHROME-B561, A SECRETORY VESICLE-SPECIFIC ELECTRON-TRANSPORT PROTEIN
PERIN, MS
FRIED, VA
SLAUGHTER, CA
SUDHOF, TC
[J]. EMBO JOURNAL, 1988, 7 (09) : 2697 - 2703
[25] CYTOCHROME-B561 CAN BE DETECTED IN MANY NEUROENDOCRINE TISSUES USING A SPECIFIC MONOCLONAL-ANTIBODY
PRUSS, RM
SHEPARD, EA
[J]. NEUROSCIENCE, 1987, 22 (01) : 149 - 157
[26] SPIRO MJ, 1961, J BIOL CHEM, V236, P225
[27] SRIVASTAVA M, 1984, J BIOL CHEM, V259, P8072
[28] OXIDOREDUCTASE ACTIVITIES OF CHROMAFFIN GRANULE GHOSTS ISOLATED FROM THE BOVINE ADRENAL-MEDULLA
TERLAND, O
FLATMARK, T
[J]. BIOCHIMICA ET BIOPHYSICA ACTA, 1980, 597 (02) : 318 - 330
[29] WAKEFIELD LM, 1986, J BIOL CHEM, V261, P9746
[30] WAKEFIELD LM, 1986, J BIOL CHEM, V261, P9739

← 1 2 3 4 →