ANTIMALARIAL ACTIVITY FROM MHEKARA (UAPACA-NITIDA MULL-ARG.), A TANZANIAN TREE

被引：14

作者：

KIRBY, GC

KHUMALONGWENYA, NB

GRAWEHR, A

FISON, TW

WARHURST, DC

PHILLIPSON, JD

机构：

[1] PERAMIHO MISSION, RUVUMA, TANZANIA

[2] UNIV LONDON SCH PHARM, DEPT PHARMACOGNOSY, LONDON WC1N 1AX, ENGLAND

来源：

JOURNAL OF ETHNOPHARMACOLOGY | 1993年 / 40卷 / 01期

基金：

英国惠康基金;

关键词：

CHEMOTHERAPY; EUPHORBIACEAE; MALARIA; PLASMODIUM-BERGHEI; PLASMODIUM-FALCIPARUM; UAPACA-NITIDA;

D O I：

10.1016/0378-8741(93)90088-M

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

An aqueous decoction of the root bark of Uapaca nitida Mull-Arg. is currently used locally at the Benedictine Mission at Peramiho in Tanzania to treat malaria. We have now demonstrated that extracts of root bark and leaves of this tree are active against the multidrug-resistant K1 strain of Plasmodium falciparum in vitro. An ethanolic extract of root bark showed activity against P. berghei in mice but at a dose which also showed toxic effects. The use of this plant in treating malaria appears to be novel and further studies would be of value.

引用

页码：47 / 51

页数：5

共 12 条

[1]

Abbiw D.K., 1990, USEFUL PLANTS GHANA

[2] DISTRIBUTION OF PHORBOL ESTER BIOACTIVITY IN THE EUPHORBIACEAE [J].