DEVELOPMENT OF NEW DNA-BINDING AND CLEAVING MOLECULES - DESIGN, SYNTHESIS AND ACTIVITY OF A BISDIAZONIUM SALT

被引：22

作者：

ARYA, DP ^{[1
]}

WARNER, PM ^{[1
]}

JEBARATNAM, DJ ^{[1
]}

机构：

[1] NORTHEASTERN UNIV,DEPT CHEM,BOSTON,MA 02115

来源：

TETRAHEDRON LETTERS | 1993年 / 34卷 / 49期

关键词：

D O I：

10.1016/S0040-4039(00)61485-5

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The bisdiazonium compound 1 has been shown to cleave DNA at concentrations as low as 0.1 mu M. Evidence is presented to indicate that 1 is binding to the minor groove of DNA, and that binding may be responsible for its effectiveness as a DNA cleaving reagent.

引用

页码：7823 / 7826

页数：4

共 14 条

[1] PHOTOHYDROLYSIS OF DNA BY POLYAMINOBENZENEDIAZONIUM SALTS
BEHR, JP
[J]. JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, 1989, (02) : 101 - 103
[2] BREGANT TM, 1993, 206TH AM CHEM SOC NA
[3] BINDING OF NONINTERCALATIVE ANTITUMOR DRUGS TO DNA-POLYMERS - STRUCTURAL EFFECTS OF BISQUATERNARY AMMONIUM HETEROCYCLES
BURCKHARDT, G
ZIMMER, C
BAGULEY, B
[J]. JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS, 1987, 4 (05) : 813 - 831
[4] DEDON PC, 1992, NUCLEIC ACID TARGETE, P475
[5] RADICAL REACTIONS OF ARENEDIAZONIUM IONS - AN EASY ENTRY INTO THE CHEMISTRY OF THE ARYL RADICAL
GALLI, C
[J]. CHEMICAL REVIEWS, 1988, 88 (05) : 765 - 792
[6] MECHANISM OF NEOCARZINOSTATIN ACTION - ROLE OF DNA MICROSTRUCTURE IN DETERMINATION OF CHEMISTRY OF BISTRANDED OXIDATIVE DAMAGE
GOLDBERG, IH
[J]. ACCOUNTS OF CHEMICAL RESEARCH, 1991, 24 (07) : 191 - 198
[7] GREENE TW, 1981, PROTECTIVE GROUPS OR
[8] CLEAVAGE OF DNA RESULTING FROM EXPOSURE TO PHENYL RADICALS
GRIFFITHS, J
MURPHY, JA
[J]. JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, 1992, (01) : 24 - 26
[9] CALICHEAMICINS - DISCOVERY, STRUCTURE, CHEMISTRY, AND INTERACTION WITH DNA
LEE, MD
ELLESTAD, GA
BORDERS, DB
[J]. ACCOUNTS OF CHEMICAL RESEARCH, 1991, 24 (08) : 235 - 243
[10] INTERACTION OF THE NONINTERCALATIVE ANTITUMOR DRUGS SN-6999 AND SN-18071 WITH DNA - INFLUENCE OF LIGAND STRUCTURE ON THE BINDING-SPECIFICITY
LUCK, G
REINERT, KE
BAGULEY, B
ZIMMER, C
[J]. JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS, 1987, 4 (06) : 1079 - 1094

← 1 2 →