CHIRAL SEPARATIONS IN SUPERCRITICAL FLUID CHROMATOGRAPHY - A MULTIVARIATE OPTIMIZATION METHOD

被引：19

作者：

PETERSSON, P ^{[1
]}

LUNDELL, N ^{[1
]}

MARKIDES, KE ^{[1
]}

机构：

[1] UNIV UPPSALA,DEPT ANALYT CHEM,POB 531,S-75121 UPPSALA,SWEDEN

来源：

JOURNAL OF CHROMATOGRAPHY | 1992年 / 623卷 / 01期

关键词：

D O I：

10.1016/0021-9673(92)85307-F

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A multivariate optimization method, based on the method of steepest ascent, is proposed for the separation of two enantiomers on a chiral stationary phase in open-tubular column supercritical fluid chromatography. The objective of the method is to optimize start density, density gradient and temperature in order to locate a desired resolution in a first step and, if desired, minimize the retention time in a second step without decrease in resolution.

引用

页码：129 / 137

页数：9

共 17 条

[1]

AICHHOLZ R, 1990, HRC-J HIGH RES CHROM, V13, P234

[2] COMPUTER-SIMULATION AS AN AID IN METHOD DEVELOPMENT FOR GAS-CHROMATOGRAPHY .1. THE ACCURATE PREDICTION OF SEPARATION AS A FUNCTION OF EXPERIMENTAL CONDITIONS [J].

BAUTZ, DE ;

DOLAN, JW ;

SNYDER, LR .

JOURNAL OF CHROMATOGRAPHY, 1991, 541 (1-2) :1-19

[3]

Bayne C. K., 1986, PRACTICAL EXPT DESIG

[4] ON THE EXPERIMENTAL ATTAINMENT OF OPTIMUM CONDITIONS [J].

BOX, GEP ;

WILSON, KB .

JOURNAL OF THE ROYAL STATISTICAL SOCIETY SERIES B-STATISTICAL METHODOLOGY, 1951, 13 (01) :1-45

[5] OPTIMIZATION OF SEPARATIONS IN SUPERCRITICAL FLUID CHROMATOGRAPHY USING A MODIFIED SIMPLEX ALGORITHM AND SHORT CAPILLARY COLUMNS [J].

CROW, JA ;

FOLEY, JP .

ANALYTICAL CHEMISTRY, 1990, 62 (04) :378-386

[6] A CRITICAL-EVALUATION OF QUALITY CRITERIA FOR THE OPTIMIZATION OF CHROMATOGRAPHIC MULTICOMPONENT SEPARATIONS [J].

DEBETS, HJG ;

BAJEMA, BL ;

DOORNBOS, DA .

ANALYTICA CHIMICA ACTA, 1983, 151 (01) :131-141

[7] COMPUTER-SIMULATION AS AN AID IN METHOD DEVELOPMENT FOR GAS-CHROMATOGRAPHY .2. CHANGES IN BAND SPACING AS A FUNCTION OF TEMPERATURE [J].

DOLAN, JW ;

SNYDER, LR ;

BAUTZ, DE .

JOURNAL OF CHROMATOGRAPHY, 1991, 541 (1-2) :21-34

[8]

DOLAN JW, 1990, LC GC EUR, V3, P17

[9]

Jandera P., 1985, GRADIENT ELUTION COL

[10]

JOHNSON DF, 1992, J CHROMATOGR, V549, P283

← 1 2 →