CHIRAL SEPARATIONS IN SUPERCRITICAL FLUID CHROMATOGRAPHY - A MULTIVARIATE OPTIMIZATION METHOD

被引：19

作者：

PETERSSON, P ^{[1
]}

LUNDELL, N ^{[1
]}

MARKIDES, KE ^{[1
]}

机构：

[1] UNIV UPPSALA,DEPT ANALYT CHEM,POB 531,S-75121 UPPSALA,SWEDEN

来源：

JOURNAL OF CHROMATOGRAPHY | 1992年 / 623卷 / 01期

关键词：

D O I：

10.1016/0021-9673(92)85307-F

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A multivariate optimization method, based on the method of steepest ascent, is proposed for the separation of two enantiomers on a chiral stationary phase in open-tubular column supercritical fluid chromatography. The objective of the method is to optimize start density, density gradient and temperature in order to locate a desired resolution in a first step and, if desired, minimize the retention time in a second step without decrease in resolution.

引用

页码：129 / 137

页数：9

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