Efficient all-optical modulation of mid-infrared radiations based on photoinduced intersubband absorption of a GaAs/AlGaAs multiquantum well structure is demonstrated at room temperature. The sample-designed for mid-infrared waveguiding was grown by molecular beam epitaxy. A double-resonance spectroscopy of both interband and intersubband transitions of the quantum wells is presented. The intersubband resonance is found at 9.56-mu-m. An AlGaAs laser diode is used to optically pump the quantum wells. On/off modulation ratios as high as 150:1 are obtained with only 45 mW pump power and for mid-infrared input powers up to 0.5 W. The frequency bandwidth of the device is presently comparable to that of acousto-optic modulators available at mid-infrared wavelengths.