CORRELATIONS BETWEEN CHANGES IN DISABILITY AND T-2-WEIGHTED BRAIN MRI ACTIVITY IN MULTIPLE-SCLEROSIS - A FOLLOW-UP-STUDY

被引：234

作者：

FILIPPI, M

PATY, DW

KAPPOS, L

BARKHOF, F

COMPSTON, DAS

THOMPSON, AJ

ZHAO, GJ

WILES, CM

MCDONALD, WI

MILLER, DH

机构：

[1] UCL INST NEUROL, NMR RES UNIT, LONDON WC1N 3BG, ENGLAND

[2] UNIV BRITISH COLUMBIA, DEPT MED, DIV NEUROL, VANCOUVER, BC V6T 1W5, CANADA

[3] UNIV WURZBURG, DEPT NEUROL, CLIN RES UNIT MULTIPLE SCLEROSIS, WURZBURG, GERMANY

[4] UNIV BASEL, KANTONSSPITAL BASEL, NEUROL KLIN, CH-4003 BASEL, SWITZERLAND

[5] FREE UNIV AMSTERDAM, DEPT DIAGNOST RADIOL, AMSTERDAM, NETHERLANDS

[6] UNIV CAMBRIDGE, ADDENBROOKES HOSP, NEUROL UNIT, CAMBRIDGE, ENGLAND

[7] ST THOMAS HOSP, LONDON, ENGLAND

来源：

NEUROLOGY | 1995年 / 45卷 / 02期

关键词：

D O I：

10.1212/WNL.45.2.255

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

We obtained two conventional unenhanced T-2-weighted brain MRI scans, separated by an interval of 24 to 36 months, in 281 patients with multiple sclerosis (MS). At the time of each scan, clinical disability was rated using the Kurtake Expanded Disability Status Scale (EDSS). Changes in disability between the two examinations correlated weakly but significantly with the number of new (Spearman's rank correlation coefficient = 0.13; p = 0.02) and enlarging (Spearman's rank correlation coefficient = 0.18; p = 0.002) MRI lesions. This result suggests that brain T-2-weighted MRI is a useful supplementary marker of disease activity in definitive (phase III) clinical treatment trials in MS.

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页码：255 / 260

页数：6

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