DIGITOXIN METABOLISM BY LIVER MICROSOMAL CYTOCHROME-P-450 AND UDP-GLUCURONOSYLTRANSFERASE AND ITS ROLE IN THE PROTECTION OF RATS FROM DIGITOXIN TOXICITY BY PREGNENOLONE-16-ALPHA-CARBONITRILE

被引：15

作者：

ARLOTTO, MP ^{[1
]}

SONDERFAN, AJ ^{[1
]}

MCKINNEY, MM ^{[1
]}

PARKINSON, A ^{[1
]}

机构：

[1] UNIV KANSAS,MED CTR,DEPT PHARMACOL TOXICOL & THERAPEUT,KANSAS CITY,KS 66103

来源：

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS | 1986年 / 251卷 / 01期

关键词：

D O I：

10.1016/0003-9861(86)90065-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

引用

页码：188 / 197

页数：10

共 34 条

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[3] CASTLE MC, 1973, RES COMMUN CHEM PATH, V5, P99
[4] EFFECT OF PRETREATMENT WITH SPIRONOLACTONE, PHENOBARBITAL OR BETA-DIETHYLAMINOETHYL DIPHENYLPROPYLACETATE (SKF 525-A) ON TRITIUM LEVELS IN BLOOD, HEART AND LIVER OF RATS AT VARIOUS TIMES AFTER ADMINISTRATION OF [H-3] DIGITOXIN
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[6] AGE-DEPENDENT AND SEX-DEPENDENT INDUCTION OF LIVER MICROSOMAL BENZO[A]PYRENE HYDROXYLASE-ACTIVITY IN RATS TREATED WITH PREGNENOLONE-16-ALPHA-CARBONITRILE (PCN)
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[8] HENRY RJ, 1960, AM J CLIN PATHOL, V34, P381
[9] HEUMAN DM, 1982, MOL PHARMACOL, V21, P753
[10] SEX DIFFERENCE OF CYTOCHROME-P-450 IN THE RAT - PURIFICATION, CHARACTERIZATION, AND QUANTITATION OF CONSTITUTIVE FORMS OF CYTOCHROME-P-450 FROM LIVER-MICROSOMES OF MALE AND FEMALE RATS
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[J]. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 1983, 225 (02) : 758 - 770

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