DIGITOXIN METABOLISM BY LIVER MICROSOMAL CYTOCHROME-P-450 AND UDP-GLUCURONOSYLTRANSFERASE AND ITS ROLE IN THE PROTECTION OF RATS FROM DIGITOXIN TOXICITY BY PREGNENOLONE-16-ALPHA-CARBONITRILE

被引：15

作者：

ARLOTTO, MP ^{[1
]}

SONDERFAN, AJ ^{[1
]}

MCKINNEY, MM ^{[1
]}

PARKINSON, A ^{[1
]}

机构：

[1] UNIV KANSAS,MED CTR,DEPT PHARMACOL TOXICOL & THERAPEUT,KANSAS CITY,KS 66103

来源：

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS | 1986年 / 251卷 / 01期

关键词：

D O I：

10.1016/0003-9861(86)90065-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

引用

页码：188 / 197

页数：10

共 34 条

[21] STIMULATION OF GLUCURONIDATION OF DIGITOXIGENIN-MONODIGITOXOSIDE BY LIVER HOMOGENATES FROM SPIRONOLACTONE-PRETREATED RATS [J].

RICHARDS, LG ;

LAGE, GL .

TOXICOLOGY AND APPLIED PHARMACOLOGY, 1977, 42 (02) :309-318

[22]

RYAN DE, 1984, J BIOL CHEM, V259, P1239

[23] INCREASED DIGITOXIN CLEAVAGE BY LIVER-MICROSOMES OF SPIRONOLACTONE-PRETREATED RATS [J].

SCHMOLDT, A .

NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 1978, 305 (03) :261-263

[24] DEHYDRO-DIGITOXOSIDES OF DIGITOXIGENIN - FORMATION AND IMPORTANCE FOR DIGITOXIN METABOLISM IN RAT [J].

SCHMOLDT, A ;

ROHLOFF, C .

NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 1978, 305 (02) :167-172

[25] ON THE SUBSTRATE-SPECIFICITY OF THE DIGITOXIGENIN MONODIGITOXOSIDE CONJUGATING UDP-GLUCURONYLTRANSFERASE IN RAT-LIVER [J].

SCHMOLDT, A ;

PROMIES, J .

BIOCHEMICAL PHARMACOLOGY, 1982, 31 (13) :2285-2289

[26]

SEYLE H, 1971, J PHARM SCI, V60, P1

[27]

SONDERFAM AJ, 1986, TOXICOLOGIST, V6, P274

[28]

THOMAS PE, 1981, J BIOL CHEM, V256, P1044

[29] HIGHLY SENSITIVE RADIOMETRIC ASSAY FOR ZOXAZOLAMINE HYDROXYLATION BY LIVER MICROSOMAL CYTOCHROME-P-450 AND P-448 - PROPERTIES OF MEMBRANE-BOUND AND PURIFIED RECONSTITUTED SYSTEM [J].

TOMASZEWSKI, JE ;

JERINA, DM ;

LEVIN, W ;

CONNEY, AH .

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 1976, 176 (02) :788-798

[30] INDUCTION STUDIES ON THE FUNCTIONAL-HETEROGENEITY OF RAT-LIVER UDP-GLUCURONOSYLTRANSFERASES [J].

WATKINS, JB ;

GREGUS, Z ;

THOMPSON, TN ;

KLAASSEN, CD .

TOXICOLOGY AND APPLIED PHARMACOLOGY, 1982, 64 (03) :439-446

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