DIGITOXIN METABOLISM BY LIVER MICROSOMAL CYTOCHROME-P-450 AND UDP-GLUCURONOSYLTRANSFERASE AND ITS ROLE IN THE PROTECTION OF RATS FROM DIGITOXIN TOXICITY BY PREGNENOLONE-16-ALPHA-CARBONITRILE

被引:15
作者
ARLOTTO, MP [1 ]
SONDERFAN, AJ [1 ]
MCKINNEY, MM [1 ]
PARKINSON, A [1 ]
机构
[1] UNIV KANSAS,MED CTR,DEPT PHARMACOL TOXICOL & THERAPEUT,KANSAS CITY,KS 66103
关键词
D O I
10.1016/0003-9861(86)90065-2
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
引用
收藏
页码:188 / 197
页数:10
相关论文
共 34 条
[21]   STIMULATION OF GLUCURONIDATION OF DIGITOXIGENIN-MONODIGITOXOSIDE BY LIVER HOMOGENATES FROM SPIRONOLACTONE-PRETREATED RATS [J].
RICHARDS, LG ;
LAGE, GL .
TOXICOLOGY AND APPLIED PHARMACOLOGY, 1977, 42 (02) :309-318
[22]  
RYAN DE, 1984, J BIOL CHEM, V259, P1239
[23]   INCREASED DIGITOXIN CLEAVAGE BY LIVER-MICROSOMES OF SPIRONOLACTONE-PRETREATED RATS [J].
SCHMOLDT, A .
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 1978, 305 (03) :261-263
[24]   DEHYDRO-DIGITOXOSIDES OF DIGITOXIGENIN - FORMATION AND IMPORTANCE FOR DIGITOXIN METABOLISM IN RAT [J].
SCHMOLDT, A ;
ROHLOFF, C .
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 1978, 305 (02) :167-172
[25]   ON THE SUBSTRATE-SPECIFICITY OF THE DIGITOXIGENIN MONODIGITOXOSIDE CONJUGATING UDP-GLUCURONYLTRANSFERASE IN RAT-LIVER [J].
SCHMOLDT, A ;
PROMIES, J .
BIOCHEMICAL PHARMACOLOGY, 1982, 31 (13) :2285-2289
[26]  
SEYLE H, 1971, J PHARM SCI, V60, P1
[27]  
SONDERFAM AJ, 1986, TOXICOLOGIST, V6, P274
[28]  
THOMAS PE, 1981, J BIOL CHEM, V256, P1044
[29]   HIGHLY SENSITIVE RADIOMETRIC ASSAY FOR ZOXAZOLAMINE HYDROXYLATION BY LIVER MICROSOMAL CYTOCHROME-P-450 AND P-448 - PROPERTIES OF MEMBRANE-BOUND AND PURIFIED RECONSTITUTED SYSTEM [J].
TOMASZEWSKI, JE ;
JERINA, DM ;
LEVIN, W ;
CONNEY, AH .
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 1976, 176 (02) :788-798
[30]   INDUCTION STUDIES ON THE FUNCTIONAL-HETEROGENEITY OF RAT-LIVER UDP-GLUCURONOSYLTRANSFERASES [J].
WATKINS, JB ;
GREGUS, Z ;
THOMPSON, TN ;
KLAASSEN, CD .
TOXICOLOGY AND APPLIED PHARMACOLOGY, 1982, 64 (03) :439-446