IN VITRO EFFECT OF SOME CHEMICALS ON HISTAMINOPEXY .2. QUANTIFICATION AND POTENTIATION OF HISTAMINOPEXY

被引：1

作者：

COHEN, ML

NIEFORTH, KA

机构：

[1] Medicinal Chemistry Laboratory, Pharmacy Research Institute, School of Pharmacy, University of Connecticut, Storrs, Connecticut

来源：

JOURNAL OF PHARMACEUTICAL SCIENCES | 1969年 / 58卷 / 01期

关键词：

Histamine dihydrochloride; radioactive—dialysis rate; Histaminopexy—in vitro determination; Membrane binding—labeled histamine; Protein binding—labeled histamine; Quercetin; di‐ and thymoquinone effect—histamine binding;

D O I：

10.1002/jps.2600580120

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Optimum conditions for histaminopexic determinations were defined resulting in complete dialysis in 18 hr. at 25°. Complexation of histamine with the dialysis membrane was found to be significant and dependent upon histamine concentration. Due to lack of predictability, individual corrections for this phenomenon were made for each determination. The interaction of gamma globulin was found to follow the law of mass action and was enhanced by quercetin. Copyright © 1969 Wiley‐Liss, Inc., A Wiley Company

引用

页码：97 / &