ENZYMATIC KINETIC RESOLUTION OF [4](1,2)FERROCENOPHANE DERIVATIVES

The enol acetate of (+/-)-[4](1,2)ferrocenophan-1-one was enantioselectively hydrolyzed by using lipase PS to afford(+)-(R)-[4](1,2)ferrocenophan-1-one and (+)-(S)-1-acetoxy[4](1,2)ferrocenophan-1-ene. By using lipase PS or lipozyme, (+/-)-1-acetoxy[4](1,2)ferrocenophane was resolved into the (+)-(1R)-alcohol and the (-)-(1S)-acetate. The lipase-mediated transesterification and esterification of (+/-)-1-hydroxy[4](1,2)ferrocenophane led to the formation of the (+)-(1R)-ester and the (-)-(1S)-alcohol.