DRAMATIC DIFFERENCES IN THE EFFECTIVENESS AMONG VARIOUS COUPLING METHODS IN THE SYNTHESIS OF PEPTIDES CONTAINING ALPHA,ALPHA-DIPHENYLGLYCINE

被引：14

作者：

YAMADA, T

OMOTE, Y

NAKAMURA, Y

MIYAZAWA, T

KUWATA, S

机构：

来源：

CHEMISTRY LETTERS | 1993年 / 09期

关键词：

D O I：

10.1246/cl.1993.1583

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Both couplings of N-benzyloxycarbonyl-alpha,alpha-diphenylglycine (Z-Dph) with methyl esters of various amino acids (AA-OMe) and Z-AA with Dph-OMe by various methods can yield Z-Dph-AA-OMe and Z-AA-Dph-OMe, respectively. Yields of the dipeptides remarkably differ from over 90% to 0% depending on the coupling method employed.

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页码：1583 / 1586

页数：4

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