HEPATIC 3-HYDROXY-3-METHYLGLUTARYL COENZYME-A REDUCTASE-ACTIVITY AND CHOLESTEROL 7ALPHA-HYDROXYLASE ACTIVITY IN NEONATAL GUINEA-PIG

被引：18

作者：

LI, JR ^{[1
]}

SUBBIAH, MTR ^{[1
]}

KOTTKE, BA ^{[1
]}

机构：

[1] UNIV CINCINNATI,MED CTR,LIPID RES CTR,CINCINNATI,OH 45229

来源：

STEROIDS | 1979年 / 34卷 / 01期

关键词：

D O I：

10.1016/0039-128X(79)90125-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Optimal assay conditions for hepatic HMG-CoA reductase activity and cholesterol 7α-hydroxylase activity in the guinea pig were determined. These two enzyme activities were studied in the liver of newborn guinea pigs during the first three postnatal weeks. Hepatic HMG-CoA reductase activity of neonatal guinea pigs was similar to that of adult animals. However, cholesterol 7α-hydroxylase activity of newborns was about one-third of that in adult guinea pigs. This finding suggests that the system for bile acid synthesis in the neonatal guinea pigs is underdeveloped. © 1979.

引用

页码：47 / 55

页数：9

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