HEPATIC 3-HYDROXY-3-METHYLGLUTARYL COENZYME-A REDUCTASE-ACTIVITY AND CHOLESTEROL 7ALPHA-HYDROXYLASE ACTIVITY IN NEONATAL GUINEA-PIG

被引：18

作者：

LI, JR ^{[1
]}

SUBBIAH, MTR ^{[1
]}

KOTTKE, BA ^{[1
]}

机构：

[1] UNIV CINCINNATI,MED CTR,LIPID RES CTR,CINCINNATI,OH 45229

来源：

STEROIDS | 1979年 / 34卷 / 01期

关键词：

D O I：

10.1016/0039-128X(79)90125-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Optimal assay conditions for hepatic HMG-CoA reductase activity and cholesterol 7α-hydroxylase activity in the guinea pig were determined. These two enzyme activities were studied in the liver of newborn guinea pigs during the first three postnatal weeks. Hepatic HMG-CoA reductase activity of neonatal guinea pigs was similar to that of adult animals. However, cholesterol 7α-hydroxylase activity of newborns was about one-third of that in adult guinea pigs. This finding suggests that the system for bile acid synthesis in the neonatal guinea pigs is underdeveloped. © 1979.

引用

页码：47 / 55

页数：9

共 22 条

[11]

MCNAMARA DJ, 1972, J BIOL CHEM, V247, P5805

[12] SUB-MICROSOMAL LOCALIZATION OF 3-HYDROXY-3-METHYLGLUTARYL-COENZYME-A REDUCTASE, CHOLESTEROL 7 ALPHA-HYDROXYLASE AND CHOLESTEROL IN RAT-LIVER [J].

MITROPOULOS, KA ;

VENKATESAN, S ;

BALASUBRAMANIAM, S ;

PETERS, TJ .

EUROPEAN JOURNAL OF BIOCHEMISTRY, 1978, 82 (02) :419-429

[13] CONTROL OF SERUM-CHOLESTEROL HOMEOSTASIS BY CHOLESTEROL IN MILK OF SUCKLING RAT [J].

REISER, R ;

SIDELMAN, Z .

JOURNAL OF NUTRITION, 1972, 102 (08) :1009-&

[14]

RODWELL VW, 1973, ADV ENZYMOL RAMB, V38, P373

[15]

RODWELL VW, 1976, ADV LIPID RES, V14, P2

[16]

SHEFER S, 1972, J LIPID RES, V13, P402

[17]

SHEFER S, 1975, J LIPID RES, V16, P92

[18]

SHEFER S, 1968, J LIPID RES, V9, P328

[19]

SHEFFER S, 1970, J LIPID RES, V11, P404

[20] SUBCELLULAR LOCALIZATION OF 3-HYDROXY-3-METHYLGLUTARYL-COA REDUCTASE IN SACCHAROMYCES-CEREVISIAE [J].

SHIMIZU, I ;

NAGAI, J ;

HATANAKA, H ;

SAITO, E ;

KATSUKI, H .

JOURNAL OF BIOCHEMISTRY, 1971, 70 (01) :175-&

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