PEA-SEEDLING DIAMINE OXIDASE - APPLICATIONS IN SYNTHESIS AND EVIDENCE RELATING TO ITS MECHANISM OF ACTION

被引：13

作者：

CRAGG, JE ^{[1
]}

HERBERT, RB ^{[1
]}

KGAPHOLA, MM ^{[1
]}

机构：

[1] UNIV LEEDS,SCH CHEM,LEEDS LS2 9JT,W YORKSHIRE,ENGLAND

来源：

TETRAHEDRON LETTERS | 1990年 / 31卷 / 47期

关键词：

D O I：

10.1016/S0040-4039(00)97204-6

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Diamines (6)-(8) and (11) act as acceptable substrates for diamine oxidase (DAO) and the novel phenacyl derivatives (2) are obtained in satisfactory preparative yield; no enantioselectivity is observed with (11) as an enzyme substrate. Remarkably, the triamines (9) and (13) are not oxidized and, moreover, (9) acts as a notable inhibitor for the DAO catalysed oxidation of (4) and (5). Kinetic evidence relevant to the mechanism of DAO action is presented, and is discussed in terms of a model for DAO-catalysed oxidation. © 1990.

引用

页码：6907 / 6910

页数：4

共 23 条

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