STREPTOMYCES GENETICS IN THE 1990S

被引:1
作者
CHATER, KF
机构
[1] John Innes Institute, John Innes Centre for Plant Science Research, Coiney Lane, Norwich
关键词
D O I
10.1007/BF02421480
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
The 1980s were a fertile time for research in Streptomyces molecular genetics. Many important questions and possibilities have been raised. In the 1990s it should therefore be possible to formulate many very attractive research proposals, and this decade should witness a full flowering of knowledge about these fascinating bacteria. This will mean that generalizations about the molecular biology of prokaryotes will be put on a much firmer footing than has hitherto been possible with studies largely confined to rapidly growing unicellular organisms such as E. coli and B. subtilis. © 1992 Rapid Communications of Oxford Ltd.
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页码:18 / 21
页数:4
相关论文
共 28 条
[11]  
Guijarro J., Santamaria R., Schauer A., Losick R., Promoter determining the timing and spatial localization of transcription of a cloned Streptomyces coelicolor gene encoding a sporeassociated polypeptide, Journal of Bacteriology, 170, pp. 1895-1901, (1988)
[12]  
Hodgson D.A., Primary carbon metabolism, Streptomyces, (1992)
[13]  
Hopwood D.A., Kieser T., The Streptomyces genome, The Bacterial Chromosome, pp. 147-162, (1990)
[14]  
Hopwood D.A., Sherman D.H., Molecular genetics of polyketides and its comparison to fatty acid biosynthesis, Annual Review of Genetics, 24, pp. 37-66, (1990)
[15]  
Hopwood D.A., Bibb M.J., Chater K.F., Janssen G., Malpartida F., Smith C.P., Regulation of gene expression in antibiotic-producing Streptomyces, 39th Symposium of the Society for General Microbiology: Regulation of Gene Expression, (1986)
[16]  
Hutchinson C.R., Borell C.W., Otten S.L., Stutzman-Engwall K.J., Wang Y., Drug discovery and development through the genetic engineering of antibiotic-producing microorganisms, Journal of Medical Chemistry, 32, pp. 929-937, (1989)
[17]  
Hutter R., Eckhardt T., Genetic manipulation, Actinomycetes in Biotechnology, pp. 89-184, (1989)
[18]  
Kieser T., Hopwood D.A., Genetic manipulation of Streptomyces: new integrating vectors and methods for gene replacement, Methods in Enzymology, 204, pp. 430-458, (1991)
[19]  
Leblond P., Demuyter P., Simonet J.M., Decaris B., Genetic instability and hypervariability in Streptomyces ambofaciens: towards and understanding of a mechanism of genome plasticity, Molecular Microbiology, 4, pp. 707-714, (1990)
[20]  
Liras P., Asturias J.A., Martin J.F., Phosphate control sequences involved in transcriptional regulation of antibiotic biosynthesis, Trends in Biotechnology, 8, pp. 184-189, (1990)