ENDOTHELIN-1 LEVELS IN ISCHEMIA, REPERFUSION, AND HEMORRHAGIC-SHOCK IN THE CANINE INFRARENAL AORTIC REVASCULARIZATION MODEL

被引：10

作者：

EDWARDS, JD

DOVGAN, PS

ROWLEY, JM

AGRAWAL, DK

THORPE, PE

ADRIAN, TE

机构：

[1] Creighton Vascular Center, Department of Surgery, Creighton University School of Medicine, Omaha, NE

[2] Creighton Vascular Center, Department of Radiology, Creighton University School of Medicine, Omaha, NE

[3] Creighton Vascular Center, Department of Biomedical Science, Creighton University School of Medicine, Omaha, NE

来源：

EUROPEAN JOURNAL OF VASCULAR SURGERY | 1994年 / 8卷 / 06期

关键词：

ENDOTHELIN-1; ISCHEMIA; REPERFUSION INJURY;

D O I：

10.1016/S0950-821X(05)80654-1

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Endothelin-1 (ET-1) is a potent vasoconstrictive polypeptide produced from vascular endothelial cells. The effects of ischaemia, reperfusion, and exsanguination on plasma ET-1 levels were studied and compared in the mongrel dog after infrarenal aortic cross clamping. Ischaemia produced a trend toward increased ET-1 serum levels (p < 0.07 with Bonferroni correction) that did not reach significance. Plasma ET-1 levels were significantly increased during reperfusion and even further elevations were found following exsanguination. We found a 2-3 fold increase in ET-1 levels following reperfusion (Initial 3.19 +/- 0.27 pg/ml vs. Reperfusion maximum 6.32 +/- 0.72 pg/ml, Bonferroni p < 0.01). Haemorrhagic shock was associated with a 3-4 fold increase in ET-1 levels (Initial 3.19 +/- 0.27 pg/ml vs. Exsanguination maximum 8.37 +/- 0.97 pg/ml Bonferroni p < 0.001). These data reveal that ET-1 is released during reperfusion and exsanguination and may mediate remote vascular events associated with infrarenal aortic cross clamping and acute blood loss.

引用

页码：729 / 734

页数：6

共 44 条

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