PHARMACOLOGIC EFFECTS OF ST-155 (CATAPRES) AND RELATED IMIDAZOLINES IN RAT

被引：27

作者：

MALING, HM

CHO, AK

HORAKOVA, Z

WILLIAMS, MA

机构：

[1] Laboratory of Chemical Pharmacology, National Heart Institute, National Institutes of Health, Bethesda, MD

[2] Experimental Therapeutics Branch, National Heart Institute, National Institutes of Health, Bethesda, MD

来源：

PHARMACOLOGY | 1969年 / 2卷 / 06期

关键词：

D O I：

10.1159/000136038

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The pharmacologic effects of ST-155 [2-(2,6-dichlorphenylamino)-2-imida-zoline hydrochloride, Cataprcs], a new hypotensive drug, were compared in the rat with those of two related imidazolines, naphazoline and tolazoline. Of the three imidazolines, only ST-155 produced postural hypotension in response to tilting and prevented the increased motor activity produced by dextroamphetamine in young rats. Peripherally, both ST-155 and naphazoline elicited alpha sympathomimetic effects. ST-155 was more potent in this regard. Tolazoline acted on alpha sites mainly as a blocking agent. © 1969 S. Karger AG, Basel.

引用

页码：337 / &