GAMBIERIC ACIDS, NEW POTENT ANTIFUNGAL SUBSTANCES WITH UNPRECEDENTED POLYETHER STRUCTURES FROM A MARINE DINOFLAGELLATE GAMBIERDISCUS-TOXICUS

被引：147

作者：

NAGAI, H

MURATA, M

TORIGOE, K

SATAKE, M

YASUMOTO, T

机构：

[1] TOHOKU UNIV,FAC AGR,SENDAI 981,JAPAN

[2] TAIYO FISHERY CO,CENT RES INST,TSUKUBA 30042,JAPAN

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1992年 / 57卷 / 20期

关键词：

D O I：

10.1021/jo00046a029

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

From the dinoflagellate Gambierdiscus toxicus, we isolated gambieric acids A, B, C, and D which possess highly potent antifungal properties. The structures of gambieric acids A and B were elucidated from two-dimensional NMR data; they have novel brevetoxin-type structures consisting of nine contiguous ether rings (7/6/6/7/9/6/6/6/6) and one isolated tetrahydrofuran. Gambieric acids C and D are 3-methylhemiglutarates of gambieric acids A and B.

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页码：5448 / 5453

页数：6

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