MECHANISMS OF ILLEGITIMATE RECOMBINATION

被引：80

作者：

EHRLICH, SD

BIERNE, H

DALENCON, E

VILETTE, D

PETRANOVIC, M

NOIROT, P

MICHEL, B

机构：

[1] Laboratoire de Génétique Microbienne, Institut National de la Recherche Agronomique

来源：

GENE | 1993年 / 135卷 / 1-2期

关键词：

RECOMBINANT DNA; GENOME REARRANGEMENT; COPY-CHOICE MODEL; PAUSING; REPLICATION FORK; HOT SPOT; ROLLING CIRCLE; ORI; DIRECT REPEATS; TRANSPOSON EXCISION;

D O I：

10.1016/0378-1119(93)90061-7

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Illegitimate recombination, which is one of the major causes of genome rearrangements, can occur in a number of ways. These might involve enzymes which cut and join DNA or enzymes which replicate DNA, as illustrated by two examples: (i) formation of deletions at the replication origin (or i) of an Escherichia coli bacteriophage, M13; and (ii) excision of E. coli transposon TnlO. It is proposed that a common theme to various ways by which illegitimate recombination can occur might be the capacity to create ends in the DNA molecule and to make the ends meet.

引用

收藏

页码：161 / 166

页数：6

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