PROLONGED MYASTHENIC SYNDROME AFTER ONE WEEK OF MUSCLE-RELAXANTS

被引：30

作者：

BENZING, G

IANNACCONE, ST

BOVE, KE

KEEBLER, PJ

SHOCKLEY, LL

机构：

[1] Department of Pediatrics, University of Cincinnati College of Medicine, Children's Hospital Medical Center, Cincinnati, OH

[2] Department of Neurology, University of Cincinnati College of Medicine, Children's Hospital Medical Center, Cincinnati, OH

[3] Department of Pathology, University of Cincinnati College of Medicine, Children's Hospital Medical Center, Cincinnati, OH

[4] Department of Physical Medicine and Rehabilitation, University of Cincinnati College of Medicine, Children's Hospital Medical Center, Cincinnati, OH

来源：

PEDIATRIC NEUROLOGY | 1990年 / 6卷 / 03期

关键词：

D O I：

10.1016/0887-8994(90)90062-6

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

A child developed severe, generalized muscle weakness which persisted for 6 weeks, after receiving muscle relaxants for 1 week while requiring ventilator support. Electrodiagnostic studies indicated a presynaptic disorder of the neuromuscular junction which improved with high-frequency stimulation, similar to findings in Lambert-Eaton syndrome. Muscle specimens exhibited neurogenic targetoid fiber atrophy. Ultrastructure of the neuromuscular junction indicated terminal axon degeneration and atrophy with depletion of the secretory vesicles. Most reported patients with post-ventilator paresis have received steroids and muscle relaxants; muscle weakness commonly has been brief and attributed to steroids. We believe that this reversible myasthenic syndrome probably represents neurotoxicity due to high doses of steroidal nondepolarizing blocking agents; however, available data are insufficient to resolve this controversy. © 1990.

引用

页码：190 / 196

页数：7