POST-TETANIC POTENTIATION IN THE INNERVATED SMOOTH-MUSCLE PREPARATION OF THE GUINEA-PIG ILEUM

被引：16

作者：

KADLEC, O ^{[1
]}

MASEK, K ^{[1
]}

SEFERNA, I ^{[1
]}

机构：

[1] CHARLES UNIV, FAC PEDIAT MED, DEPT PHARMACOL, CS-12800 PRAGUE 2, CZECHOSLOVAKIA

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1979年 / 60卷 / 04期

关键词：

Cholinergic transmission; Guinea-pig ileum; Muscarinic synapse; Naloxone; Post-tetanic potentiation; Prostaglandins;

D O I：

10.1016/0014-2999(79)90247-4

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The phenomenon of posttetanic potentiation of electrically evoked twitch contractions in the myenteric plexus-longitudinal muscle of the guinea-pig ileum was observed when (1) post-tetanic inhibition had been prevented by naloxone, an opiate receptor antagonist, and (2) the twitches had been diminished by indomethacin, an inhibitor of prostaglandin synthesis. The origin of posttetanic potentiation at this muscarinic synapse appeared to be presynaptic. © 1979.

引用

页码：383 / 386

页数：4