OLIGOSACCHARIDE CHARACTERIZATION USING COLLISION-INDUCED DISSOCIATION FAST-ATOM-BOMBARDMENT MASS-SPECTROMETRY - EVIDENCE FOR INTERNAL MONOSACCHARIDE RESIDUE LOSS

被引:82
作者
KOVACIK, V
HIRSCH, J
KOVAC, P
HEERMA, W
THOMASOATES, J
HAVERKAMP, J
机构
[1] NIDDK,BETHESDA,MD 20892
[2] UNIV UTRECHT,FAC CHEM,BIJVOET CTR BIOMOLEC RES,3505 TB UTRECHT,NETHERLANDS
来源
JOURNAL OF MASS SPECTROMETRY | 1995年 / 30卷 / 07期
关键词
D O I
10.1002/jms.1190300704
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
The protonated and sodium cationized pseudomolecular ions of a series of reducing and non-reducing oligosaccharides possessing aldopentopyranosyl, 6-deoxyaldohexopyranosyl, ketohexofuranosyl, 4-O-methyl glucuronopyranosyl methyl ester and N-acetyl 2-deoxyglucopyranosylamine units were studied using collision-induced dissociation (CID) fast atom bombardment (FAB) mass spectrometry. The CID spectra of the [M + H](+) ions provide information about the sequence of the monosaccharide units, while dissociation of the [M + Na](+) ions by two-bond ring cleavage processes gives rise to fragment ions which allow differentiation of 1 --> 2 and 1 --> 4 linkages, The influence of the structure of the constituent monosaccharides on the dissociation of the [M + H](+) and [M + Na](+) ions is discussed, An unusual type of fragmentation, which we suggest involves the elimination of internal monosaccharides residues, has not only been observed in the FAB mass spectra but also in the unimolecular decomposition and CID spectra of both [M + H](+) ions and oxonium ions from several oligosaccharides containing monosaccharide residues with different masses.
引用
收藏
页码:949 / 958
页数:10
相关论文
共 22 条
[11]   SYNTHESIS OF A SERIES OF METHYL BETA-GLYCOSIDES OF (1-]6)-BETA-D-GALACTO-OLIGOSACCHARIDES HAVING ONE RESIDUE DEOXYGENATED AT POSITION-3 [J].
KOVAC, P ;
EDGAR, KJ .
CARBOHYDRATE RESEARCH, 1990, 201 (01) :79-93
[12]  
KOVAC P, 1978, CHEM ZVESTI, V32, P501
[13]   ALTERNATIVE SYNTHESIS OF METHYLATED SUGARS .23. STEPWISE SYNTHESIS OF METHYL 4-O-[3-O-(BETA-D-XYLOPYRANOSYL)-BETA-D-XYLOPYRANOSYL]-BETA-D-XYLOPYRANOSIDE [J].
KOVAC, P ;
HIRSCH, J .
CARBOHYDRATE RESEARCH, 1980, 79 (02) :303-307
[14]   ALTERNATIVE SYNTHESES OF METHYLATED SUGARS .19. STEPWISE SYNTHESIS OF A METHYL BETA-XYLOTETRAOSIDE RELATED TO BRANCHED XYLANS [J].
KOVAC, P ;
HIRSCH, J ;
KOVACIK, V .
CARBOHYDRATE RESEARCH, 1979, 75 (OCT) :109-116
[15]  
KOVAC P, 1992, J ORG CHEM, V2, P2455
[16]   FAST-ATOM-BOMBARDMENT MASS AND TANDEM MASS-SPECTRA OF PROTONATED AND ALKALI CATIONIZED ALDOBIOURONIC AND PSEUDOALDOBIOURONIC ACID PER-O-METHYL DERIVATIVES [J].
KOVACIK, V ;
HIRSCH, J ;
HEERMA, W ;
DEKOSTER, CG ;
HAVERKAMP, J .
ORGANIC MASS SPECTROMETRY, 1994, 29 (12) :707-712
[17]   ENHANCED STRUCTURAL INFORMATION ON OLIGOSACCHARIDES BY SCAN OF LINKED MAGNETIC AND ELECTROSTATIC FIELDS (B/E) AND NEUTRAL GAS COLLISION FAST-ATOM-BOMBARDMENT MASS-SPECTROMETRY (FABMS) [J].
KOVACK, V ;
LEE, HK ;
KOVAC, P .
CARBOHYDRATE RESEARCH, 1993, 239 :61-70
[18]  
LAINE R A, 1990, P539
[19]   COLLISION-INDUCED DISSOCIATION OF ALKALI-METAL CATIONIZED AND PERMETHYLATED OLIGOSACCHARIDES - INFLUENCE OF THE COLLISION ENERGY AND OF THE COLLISION GAS FOR THE ASSIGNMENT OF LINKAGE POSITION [J].
LEMOINE, J ;
FOURNET, B ;
DESPEYROUX, D ;
JENNINGS, KR ;
ROSENBERG, R ;
DEHOFFMANN, E .
JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY, 1993, 4 (03) :197-203