MECHANISM OF INHIBITION OF LIPID-PEROXIDATION BY TAMOXIFEN AND 4-HYDROXYTAMOXIFEN INTRODUCED INTO LIPOSOMES - SIMILARITY TO CHOLESTEROL AND ERGOSTEROL

被引：44

作者：

WISEMAN, H

CANNON, M

ARNSTEIN, HRV

HALLIWELL, B

机构：

[1] Department of Biochemistry, University of London, King's College, London, WC2R 2LS, Strand Campus

来源：

FEBS LETTERS | 1990年 / 274卷 / 1-2期

关键词：

4-Hydroxytamoxifen; Cholesterol; Lipid peroxidation; Liposome; Membrane stabilization; Tamoxifen;

D O I：

10.1016/0014-5793(90)81341-K

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The anticancer drug tamoxifen when introduced into phospholipid liposomes during their preparation inhibited Fe(III)-ascorbate induced lipid peroxidation to a greater extent than similarly introduced cholesterol. Ergosterol was equipotent with tamoxifen, but much less effective than 4-hydroxytamoxifen. Possible mechanisms underlying these effects are discussed in relation to structural mimicry of the sterols by these triphenylethylene drugs as membrane stabilizers against lipid peroxidation. © 1990.

引用

页码：107 / 110

页数：4

共 23 条

[21] OBSERVATION AND SIGNIFICANCE OF GROWTH-INHIBITION OF SACCHAROMYCES-CEREVISIAE (A224A) BY THE ANTI-ESTROGEN DRUG TAMOXIFEN [J].