LOCALIZATION OF THE EXPRESSED HUMAN P58 PROTEIN-KINASE CHROMOSOMAL GENE TO CHROMOSOME-1P36 AND A HIGHLY RELATED SEQUENCE TO CHROMOSOME-15

被引：48

作者：

EIPERS, PG

BARNOSKI, BL

HAN, J

CARROLL, AJ

KIDD, VJ

机构：

[1] ST JUDE CHILDRENS RES HOSP, DEPT TUMOR CELL BIOL, 332 N LAUDERDALE, MEMPHIS, TN 38105 USA

[2] UNIV ALABAMA, DEPT CELL BIOL, BIRMINGHAM, AL 35294 USA

[3] UNIV ALABAMA, MED GENET LAB, BIRMINGHAM, AL 35294 USA

来源：

GENOMICS | 1991年 / 11卷 / 03期

关键词：

D O I：

10.1016/0888-7543(91)90069-Q

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The gene for the human p58 protein kinase, a cell division control-related gene, has been mapped by somatic cell hybrid analyses, in situ localization with the chromosomal gene, and nested polymerase chain reaction amplification of microdissected chromosomes. These studies indicate that the expressed p58 chromosomal gene maps to 1p36, while a highly related p58 sequence of unknown nature maps to chromosome 15. Assignment of a p34cdc2-related gene to 1p36 may have implications for numerous tumors that involve deletion of this region, including neuroblastoma, ductal carcinoma of the breast, malignant melanoma, Merkel cell carcinoma, and endocrine neoplasia. © 1991.

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页码：621 / 629

页数：9

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