Paradigm development: Comparative and predictive 3D modeling of HIV-1 Virion Infectivity Factor (vif)

被引:16
作者
Balaji, Seetharaaman [1 ,2 ]
Kalpana, Rangaswamy [3 ]
Shapshak, Paul [4 ]
机构
[1] SASTRA Deemed Univ, Sch Chem & Biotechnol, Bioinformat, Thanjavur, Tamil Nadu, India
[2] Indian Inst Spices Res, Bioinformat, Calicut, Kerala, India
[3] Bharathiar Univ, CMS Coll Arts & Sci, Bioinformat, Coimbatore, Tamil Nadu, India
[4] Univ Miami, Miller Med Sch, Dept Psychiat & Behav Sci, Miami, FL 33136 USA
关键词
Vif; HIV-1; 3D structure; computer modeling; threading;
D O I
10.6026/97320630001290
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
Obtaining structural information about Vif is of interest for several reasons that include the study of the interaction of Vif with APOBEC3G, a resistance factor. Vif is a potential drug target and its function is essential for the HIV-1 infectivity process. To study Vif mechanism of action, we need to decipher its structure. Pivotal in this approach is the painstaking prediction of its protein structure. The three-dimensional (3D) crystal structure for Vif has not been established. In order to understand its mechanism of action, information on the structure of Vif is very much needed. Therefore we undertook this study based on the hypothesis that information from structurally homologous proteins can be used to predict the 3D structure of Vif by computer modeling and threading. As a result the structure of HIV-1 Vif has been modeled and deposited in the theoretical models section and accepted with the PDB code 1VZF. Here, we present the results of the comparative modeling strategy we used to predict the 3D structure of Vif.
引用
收藏
页码:290 / 309
页数:20
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