Periodontitis and cardiovascular diseases: The link and relevant mechanisms

被引：8

作者：

Izumi, Yuichi ^{[1
,2
]}

Nagasawa, Toshiyuki ^{[3
]}

Umeda, Makoto ^{[1
]}

Kobayashi, Hiroaki ^{[1
]}

Takeuchi, Yasuo ^{[1
]}

Yashiro, Reiko ^{[1
]}

Hormdee, Doosadee ^{[4
]}

Suda, Tomonari ^{[1
]}

Ushida, Yuka ^{[1
]}

Wara-aswapati, Nawarat ^{[4
]}

机构：

[1] Tokyo Med & Dent Univ, Grad Sch, Dept Hard Tissue Engn, Sect Periodontol,Bunkyo Ku, 1-5-45 Yushima, Tokyo 1138549, Japan

[2] Tokyo Med & Dent Univ, Int Res Ctr Mol Sci Tooth & Bone Dis, GCOE Program, Tokyo, Japan

[3] Hlth Sci Univ Hokkaido, Dept Periodontol & Endodontol, Div Oral Maxiollofacial Rehabil, Tobetsu, Hokkaido, Japan

[4] Khon Kaen Univ, Fac Dent, Dept Periodontol, Khon Kaen, Thailand

来源：

JAPANESE DENTAL SCIENCE REVIEW | 2009年 / 45卷 / 02期

基金：

日本学术振兴会;

关键词：

Periodontitis; Cardiovascular diseases; Atherosclerosis; Buerger's disease; Periodontal treatment;

D O I：

10.1016/j.jdsr.2009.06.001

中图分类号：

R78 [口腔科学];

学科分类号：

1003 ;

摘要：

This paper reviews the association between periodontitis and CVD. In addition, the potential mechanisms of any association between periodontitis and CVD as well as the effects of periodontal treatment on CVD are herein discussed. Among the studies carried out by this group and others on coronary artery diseases, peripheral arterial diseases, abdominal aortic aneurysm, and Buerger's disease, periodontopathic bacteria were frequently detected in the diseased blood vessels, thus suggesting an association between periodontitis and CVD. The potential mechanisms of the association between periodontitis and CVD are not fully elucidated. However, inflammation and some autoimmune mechanisms, including molecular mimicry between the periodontopathic bacteria and host molecules, are suggested. The effects of periodontal treatment on CVD might thus vary among the different treatment modalities, and full-mouth mechanical debridement might induce strong transient systemic inflammatory responses in comparison to the quadrant-wise mechanical debridement. (C) 2009 Japanese Association for Dental Science. Published by Elsevier Ireland. All rights reserved.

引用

页码：98 / 108

页数：11

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