SYNTHESIS OF THE SULFONYL ANALOG OF HYPOXANTHINE, IMIDAZO[4,5-E]-1,2,4-THIADIAZINE 1,1-DIOXIDE

被引：10

作者：

HUANG, BS ^{[1
]}

PARHAM, JC ^{[1
]}

机构：

[1] MEM SLOAN KETTERING CANC CTR,NEW YORK,NY 10021

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1979年 / 44卷 / 23期

关键词：

D O I：

10.1021/jo01337a005

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The unsubstituted imidazo[4, 5-e]-l, 2, 4-thiadiazine 1, 1-dioxide was prepared in good yield by reduction of 4(5)-nitroimidazole-5(4)-sulfonamide and immediate ring closure of the unstable aminoimidazole intermediate. Ribosylation of the product by the modified Hilbert-Johnson method afforded a single nucleoside analogue, which is shown to be the 7-(β-D-ribofuranosyl) derivative by comparison of its properties to those of the 5- and 7-methyl derivatives. © 1979, American Chemical Society. All rights reserved.

引用

页码：4046 / 4050

页数：5

共 42 条

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