HISTONES, HMG, HU, IHF - MEME COMBAT

被引：91

作者：

OBERTO, J

DRLICA, K

ROUVIEREYANIV, J

机构：

[1] INST BIOL PHYS CHIM,F-75005 PARIS,FRANCE

[2] PUBL HLTH RES INST CITY NEW YORK INC,NEW YORK,NY 10016

来源：

BIOCHIMIE | 1994年 / 76卷 / 10-11期

关键词：

HU; IHF; TF1; HMG; HISTONES;

D O I：

10.1016/0300-9084(94)90014-0

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In this review article we present a compilation of the proteins homologous to Escherichia coli HU: the HU-like family. Two of these, HU and IHF from E coli have been extensively characterized genetically and biochemically. Due to their DNA binding activities, these proteins confer a condensed shape to the chromosome and regulate the transcription of selected sets of its genes. The parallel between the dual function of the HU-like proteins and the roles described for eukaryotic histone and HMG proteins is striking, especially in the view that they are evolutionary unrelated.

引用

页码：901 / 908

页数：8