AMINATION OF ESTER ENOLATES WITH ORTHO-(2,4-DINITROPHENYL)HYDROXYLAME

被引：32

作者：

RADHAKRISHNA, AS

LOUDON, GM

MILLER, MJ

机构：

[1] PURDUE UNIV,SCH PHARM & PHARM SCI,DEPT MED CHEM & PHARMACOGNOSY,W LAFAYETTE,IN 47907

[2] UNIV NOTRE DAME,DEPT CHEM,NOTRE DAME,IN 46556

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1979年 / 44卷 / 26期

关键词：

D O I：

10.1021/jo00394a020

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The enolates derived from diethyl malonate and its 2-substituted analogues aminate in good yield with O-(2, 4-dinitrophenyl)hydroxylamine (1) as an amino-transfer reagent. The 2-aminomalonates thus produced are readily converted to the corresponding amino acids by hydrolysis and decarboxylation. As the ester enolates become more basic, less amino-group transfer is observed, although the aminating reagent 1 is converted to. © 1979, American Chemical Society. All rights reserved.

引用

页码：4836 / 4841

页数：6