DIRECT EVIDENCE FOR THE ROLE OF COOH TERMINUS OF MOUSE MAMMARY-TUMOR VIRUS SUPERANTIGEN IN DETERMINING T-CELL RECEPTOR V-BETA SPECIFICITY

被引:42
作者
YAZDANBAKHSH, K
PARK, CG
WINSLOW, GM
CHOI, YW
机构
[1] ROCKEFELLER UNIV, HOWARD HUGHES MED INST, 1230 YORK AVE, NEW YORK, NY 10021 USA
[2] NATL JEWISH CTR IMMUNOL & RESP MED, DEPT MED, DIV BASIC IMMUNOL, DENVER, CO 80206 USA
关键词
D O I
10.1084/jem.178.2.737
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
It has recently been shown that open reading frames in the 3' long terminal repeats of mouse mammary tumor viruses encode superantigens. These viral superantigens (vSAGs) stimulate most T cells expressing appropriate Vbetas almost regardless of the rest of the variable components of the T cell receptors (TCR) expressed by those cells. vSAGs produce a type II integral membrane protein with a nonessential short cytoplasmic domain and a large glycosylated extracellular COOH-terminal domain, which is predicted to interact with major histocompatibility complex class II molecules and the TCR. The transmembrane region of vSAG also has an internal positively charged lysine residue of unknown significance. A set of chimeric and mutant vSAG genes has been used in transfection experiments to show that only the extreme COOH-terminal portion of vSAGs determine their TCR Vbeta specificities, and to show that the lysine residue in the transmembrane domain is not essential for the function of vSAG.
引用
收藏
页码:737 / 741
页数:5
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